| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1Department of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298-0709; and 2Department of Psychology and Neuroscience, The University of Lethbridge, Lethbridge, Alberta T1K 3M4, Canada
Submitted 18 March 2004; accepted in final form 15 April 2004
Cortical binocularity is abolished by monocular deprivation (MD) during a critical period of development lasting from approximately postnatal day (P) 35 to P70 in ferrets. Although this is one of the best-characterized models of neural plasticity and amblyopia, very few studies have examined the requirements for recovery of cortical binocularity and orientation selectivity of deprived eye responses. Recent studies indicating that different mechanisms regulate loss and recovery of binocularity raise the possibility that different sensitive periods characterize loss and recovery of deprived eye responses. In this report, we have examined whether the potential for recovery of binocularity and orientation selectivity is restricted to the critical period. Quantitative single unit recordings revealed recovery of cortical binocularity and full recovery of orientation selectivity of deprived eye responses following prolonged periods of MD (i.e., >3 wk) starting at P49, near the peak of plasticity. Surprisingly, recovery was present when binocular vision was restored after the end of the critical period for ocular dominance plasticity, as late as P83. In contrast, ferrets that had never received visual experience through the deprived eye failed to recover binocularity even though normal binocular vision was restored at P50, halfway through the critical period. Collectively, these results indicate that there is potential for recovery of cortical binocularity and deprived eye orientation selectivity after the end of the critical period for ocular dominance plasticity.
This article has been cited by other articles:
|
|
 |
|
  D. J. Wallace and B. Sakmann Plasticity of Representational Maps in Somatosensory Cortex Observed by In Vivo Voltage-Sensitive Dye Imaging Cereb Cortex, June 1, 2008; 18(6): 1361 - 1373. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Pizzorusso, P. Medini, S. Landi, S. Baldini, N. Berardi, and L. Maffei Structural and functional recovery from early monocular deprivation in adult rats PNAS, May 30, 2006; 103(22): 8517 - 8522. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Sakai, H. Bi, I. Maruko, B. Zhang, J. Zheng, J. Wensveen, R. S. Harwerth, E. L. Smith III, and Y. M. Chino Cortical Effects of Brief Daily Periods of Unrestricted Vision During Early Monocular Form Deprivation J Neurophysiol, May 1, 2006; 95(5): 2856 - 2865. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Faulkner, V. Vorobyov, and F. Sengpiel Visual Cortical Recovery From Reverse Occlusion Depends on Concordant Binocular Experience J Neurophysiol, March 1, 2006; 95(3): 1718 - 1726. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. W. Li, K. G. Young, P. Hoenig, and D. M. Levi Perceptual Learning Improves Visual Performance in Juvenile Amblyopia Invest. Ophthalmol. Vis. Sci., September 1, 2005; 46(9): 3161 - 3168. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. Chalupa Complete Restoration of Visual Cortical Responses is Possible Late in Development. Focus on "Recovery of Cortical Binocularity and Orientation Selectivity After the Critical Period for Ocular Dominance Plasticity" J Neurophysiol, October 1, 2004; 92(4): 1969 - 1970. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
