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J Neurophysiol 92: 265-279, 2004. First published February 18, 2004; doi:10.1152/jn.01090.2003
0022-3077/04 $5.00
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Centrifugal Inputs Modulate Taste Aversion Learning Associated Parabrachial Neuronal Activities

Ken'ichi Tokita1, Zoltán Karádi2, Tsuyoshi Shimura1 and Takashi Yamamoto1

1Department of Behavioral Physiology, Graduate School of Human Sciences, Osaka University, Osaka 565-0871, Japan; and 2Institute of Physiology, Neurophysiology Research Group of the Hungarian Academy of Sciences, Pécs University Medical School, H-7643 Pécs, Hungary

Submitted 11 November 2003; accepted in final form 14 February 2004

Our previous studies have demonstrated that gustatory neurons in the parabrachial nucleus (PBN) show altered responses after the acquisition of conditioned taste aversion (CTA) to NaCl. The present study was conducted 1) to examine centrifugal influences on the altered gustatory activity of CTA-trained rats, and 2) to evaluate the role of amiloride-sensitive (ASN) and -insensitive NaCl (AIN) best units in coding the taste of NaCl. Animals were separated into 2 groups: a CTA group that had acquired taste aversion to 0.1 M NaCl and a control group that underwent pseudoconditioning before the recording experiment. Single-neuron activity, in 2 separate series of experiments, was extracellularly recorded in anesthetized rats. In the stimulation studies, the effects of electrical stimulation of the gustatory cortex (GC) or the central nucleus of amygdala (CeA) were examined on firing of PBN taste units. CeA stimulation produced excitatory effect in significantly more neurons in the CTA group (n = 8) than in the control group (n = 1). Furthermore, ASN-best units in the CTA group showed larger responses to NaCl than similar units in the control group. In the decerebration experiment, there was no statistical difference among the taste responses between the 2 groups in any best-stimulus category. These results suggest that CTA conditioning uses an effective central amygdaloid input to modulate activity of gustatory neurons in the PBN. Data also substantiate that amiloride-sensitive components of NaCl-best neurons play a critical role in the recognition of distinctive taste of NaCl.

Address for reprint requests and other correspondence: T. Yamamoto, Department of Behavioral Physiology, Graduate School of Human Sciences, Osaka University, 1-2 Yamadaoka, Suita, Osaka 565-0871, Japan (E-mail: yamamoto{at}hus.osaka-u.ac.jp).




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