| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Institute of Physiology, University of Bern, CH-3012 Bern, Switzerland
Submitted 2 October 2003; accepted in final form 13 November 2003
We investigated the spatiotemporal evolution of activity in the rat barrel cortex using multielectrode arrays (MEAs). In acute brain slices, field potentials were recorded simultaneously from 60 electrodes with high spatial and temporal resolution. This new technique allowed us to map functionally discrete barrels and to observe the interplay between the excitatory and inhibitory network. The local field potentials (LFPs) were elicited by focal electrical stimulation in layer 4 (L4). Excitation recorded in a single barrel was first confined to the stimulated barrel and subsequently spread in a columnar manner to layer 2/3 (L2/3). This excitation in L4 and lower L2/3 was followed by inhibition curtailing excitation to a short period lasting only 
2 ms. In the uppermost layer, a long-lasting (10 ms), laterally spreading band of excitation remained active. Blockade of GABAA-receptors resulted in a long-lasting and diffuse activation of L4 and lower L2/3 and abolition of activation of the upper L2/3. Thus inhibition not only shaped the spatial-temporal map of excitation in L4 and lower L2/3 but also resulted indirectly in an excitatory action in the superficial layers. Stimulation in L6 revealed a feedforward inhibition to L4 and subsequently an excitatory L6-L4-L6 loop. The complex interplay between excitation and inhibition opens two spatial windows of excitation in the infra- and supragranular layers. They may prepare the L5 pyramidal neuron for associating top-down input from other cortical regions with bottom-up input from the whisker pad to generate behaviorally relevant output.
This article has been cited by other articles:
|
|
 |
|
  P. Kumar and O. Ohana Inter- and Intralaminar Subcircuits of Excitatory and Inhibitory Neurons in Layer 6a of the Rat Barrel Cortex J Neurophysiol, October 1, 2008; 100(4): 1909 - 1922. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Broser, V. Grinevich, P. Osten, B. Sakmann, and D. J. Wallace Critical Period Plasticity of Axonal Arbors of Layer 2/3 Pyramidal Neurons in Rat Somatosensory Cortex: Layer-Specific Reduction of Projections into Deprived Cortical Columns Cereb Cortex, July 1, 2008; 18(7): 1588 - 1603. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Berwick, D. Johnston, M. Jones, J. Martindale, C. Martin, A. J. Kennerley, P. Redgrave, and J.E.W. Mayhew Fine Detail of Neurovascular Coupling Revealed by Spatiotemporal Analysis of the Hemodynamic Response to Single Whisker Stimulation in Rat Barrel Cortex J Neurophysiol, February 1, 2008; 99(2): 787 - 798. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Suppa, M. Bologna, F. Gilio, C. Lorenzano, J. C. Rothwell, and A. Berardelli Preconditioning Repetitive Transcranial Magnetic Stimulation of Premotor Cortex Can Reduce But Not Enhance Short-Term Facilitation of Primary Motor Cortex J Neurophysiol, February 1, 2008; 99(2): 564 - 570. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Frick, D. Feldmeyer, M. Helmstaedter, and B. Sakmann Monosynaptic Connections between Pairs of L5A Pyramidal Neurons in Columns of Juvenile Rat Somatosensory Cortex Cereb Cortex, February 1, 2008; 18(2): 397 - 406. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Tang, D. Jackson, J. Hobbs, W. Chen, J. L. Smith, H. Patel, A. Prieto, D. Petrusca, M. I. Grivich, A. Sher, et al. A Maximum Entropy Model Applied to Spatial and Temporal Correlations from Cortical Networks In Vitro J. Neurosci., January 9, 2008; 28(2): 505 - 518. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Berger, A. Borgdorff, S. Crochet, F. B. Neubauer, S. Lefort, B. Fauvet, I. Ferezou, A. Carleton, H.-R. Luscher, and C. C. H. Petersen Combined Voltage and Calcium Epifluorescence Imaging In Vitro and In Vivo Reveals Subthreshold and Suprathreshold Dynamics of Mouse Barrel Cortex J Neurophysiol, May 1, 2007; 97(5): 3751 - 3762. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. B. Simons, J. Chiu, O. V. Favorov, B. L. Whitsel, and M. Tommerdahl Duration-Dependent Response of SI to Vibrotactile Stimulation in Squirrel Monkey J Neurophysiol, March 1, 2007; 97(3): 2121 - 2129. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Quairiaux, M. Armstrong-James, and E. Welker Modified Sensory Processing in the Barrel Cortex of the Adult Mouse After Chronic Whisker Stimulation J Neurophysiol, March 1, 2007; 97(3): 2130 - 2147. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Mapelli and E. D'Angelo The Spatial Organization of Long-Term Synaptic Plasticity at the Input Stage of Cerebellum J. Neurosci., February 7, 2007; 27(6): 1285 - 1296. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Higley and D. Contreras Cellular Mechanisms of Suppressive Interactions Between Somatosensory Responses In Vivo J Neurophysiol, January 1, 2007; 97(1): 647 - 658. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Tutunculer, G. Foffani, B. T. Himes, and K. A. Moxon Structure of the Excitatory Receptive Fields of Infragranular Forelimb Neurons in the Rat Primary Somatosensory Cortex Responding To Touch Cereb Cortex, June 1, 2006; 16(6): 791 - 810. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Morita, K. Tsumoto, and K. Aihara Bidirectional Modulation of Neuronal Responses by Depolarizing GABAergic Inputs Biophys. J., March 15, 2006; 90(6): 1925 - 1938. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Morita, K. Tsumoto, and K. Aihara Possible Effects of Depolarizing GABAA Conductance on the Neuronal Input-Output Relationship: A Modeling Study J Neurophysiol, June 1, 2005; 93(6): 3504 - 3523. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Feldmeyer, A. Roth, and B. Sakmann Monosynaptic Connections between Pairs of Spiny Stellate Cells in Layer 4 and Pyramidal Cells in Layer 5A Indicate That Lemniscal and Paralemniscal Afferent Pathways Converge in the Infragranular Somatosensory Cortex J. Neurosci., March 30, 2005; 25(13): 3423 - 3431. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
