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J Neurophysiol (March 1, 2003). 10.1152/jn.00271.2001
Submitted on Submitted 5 April 2001; accepted in final form 4 October 2002
Laboratory of Auditory Neurophysiology, Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
Kadia, Siddhartha C. and
Xiaoqin Wang.
Spectral Integration in A1 of Awake Primates: Neurons With
Single- and Multipeaked Tuning Characteristics. J. Neurophysiol. 89: 1603-1622, 2003. We
investigated modulations by stimulus components placed outside of the
classical receptive field in the primary auditory cortex (A1) of awake
marmosets. Two classes of neurons were identified using single tone
stimuli: neurons with single-peaked frequency tuning characteristics
(147/185, 80%) and neurons with multipeaked frequency tuning
characteristics (38/185, 20%), referred to as single- and multipeaked
units, respectively. Each class of neurons was further studied using
two-tone paradigms in which the frequency, intensity, and timing of the
second tone were systematically varied while a unit was driven by the
first tone placed at a unit's characteristic frequency (CF) if it was
single-peaked or at one of multiple spectral peaks if it was
multipeaked. The main findings were: 1) excitatory spectral
peaks in the frequency tuning of the multipeaked units were often
harmonically related. 2) Multipeaked units showed
facilitation in their responses to combinations of two harmonically
related tones placed at the spectral peaks of their frequency tuning. The two-tone facilitation was strongest for the simultaneously presented tones. 3) In 76 of 113 single-peaked units studied
using the two-tone paradigm, facilitatory and/or inhibitory modulations by distant off-CF tones were observed. This distant inhibition differed
from flanking (or side-band) inhibitions near CF. 4) In
single-peaked units, the distant off-CF inhibitions were dominated by
tones at frequencies that were harmonically related to the CF of a
unit, whereas the facilitation by off-CF tones was observed for a wide
range of frequencies. And 5) in both single- and multipeaked units, sound levels of two interacting tones determined whether the two
tones produced excitation or inhibition. The largest facilitation was
achieved by using two tones at their corresponding preferred sound
levels. Together, these findings suggest that extracting or rejecting
harmonically related components embedded in complex sounds may
represent fundamental signal processing properties in different classes
of A1 neurons.
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