| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Neurophysiol (March 1, 2003). 10.1152/jn.00271.2001
Submitted on Submitted 5 April 2001; accepted in final form 4 October 2002
Laboratory of Auditory Neurophysiology, Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
Kadia, Siddhartha C. and
Xiaoqin Wang.
Spectral Integration in A1 of Awake Primates: Neurons With
Single- and Multipeaked Tuning Characteristics. J. Neurophysiol. 89: 1603-1622, 2003. We
investigated modulations by stimulus components placed outside of the
classical receptive field in the primary auditory cortex (A1) of awake
marmosets. Two classes of neurons were identified using single tone
stimuli: neurons with single-peaked frequency tuning characteristics
(147/185, 80%) and neurons with multipeaked frequency tuning
characteristics (38/185, 20%), referred to as single- and multipeaked
units, respectively. Each class of neurons was further studied using
two-tone paradigms in which the frequency, intensity, and timing of the
second tone were systematically varied while a unit was driven by the
first tone placed at a unit's characteristic frequency (CF) if it was
single-peaked or at one of multiple spectral peaks if it was
multipeaked. The main findings were: 1) excitatory spectral
peaks in the frequency tuning of the multipeaked units were often
harmonically related. 2) Multipeaked units showed
facilitation in their responses to combinations of two harmonically
related tones placed at the spectral peaks of their frequency tuning. The two-tone facilitation was strongest for the simultaneously presented tones. 3) In 76 of 113 single-peaked units studied
using the two-tone paradigm, facilitatory and/or inhibitory modulations by distant off-CF tones were observed. This distant inhibition differed
from flanking (or side-band) inhibitions near CF. 4) In
single-peaked units, the distant off-CF inhibitions were dominated by
tones at frequencies that were harmonically related to the CF of a
unit, whereas the facilitation by off-CF tones was observed for a wide
range of frequencies. And 5) in both single- and multipeaked units, sound levels of two interacting tones determined whether the two
tones produced excitation or inhibition. The largest facilitation was
achieved by using two tones at their corresponding preferred sound
levels. Together, these findings suggest that extracting or rejecting
harmonically related components embedded in complex sounds may
represent fundamental signal processing properties in different classes
of A1 neurons.
This article has been cited by other articles:
|
|
 |
|
  D. C. Peterson, K. Nataraj, and J. Wenstrup Glycinergic Inhibition Creates a Form of Auditory Spectral Integration in Nuclei of the Lateral Lemniscus J Neurophysiol, August 1, 2009; 102(2): 1004 - 1016. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Gans, K. Sheykholeslami, D. C. Peterson, and J. Wenstrup Temporal Features of Spectral Integration in the Inferior Colliculus: Effects of Stimulus Duration and Rise Time J Neurophysiol, July 1, 2009; 102(1): 167 - 180. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. N. Woolley, P. R. Gill, T. Fremouw, and F. E. Theunissen Functional Groups in the Avian Auditory System J. Neurosci., March 4, 2009; 29(9): 2780 - 2793. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Yin, M. Mishkin, M. Sutter, and J. B. Fritz Early Stages of Melody Processing: Stimulus-Sequence and Task-Dependent Neuronal Activity in Monkey Auditory Cortical Fields A1 and R J Neurophysiol, December 1, 2008; 100(6): 3009 - 3029. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Norena, B. Gourevitch, M. Pienkowski, G. Shaw, and J. J. Eggermont Increasing Spectrotemporal Sound Density Reveals an Octave-Based Organization in Cat Primary Auditory Cortex J. Neurosci., September 3, 2008; 28(36): 8885 - 8896. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. C. Peterson, S. Voytenko, D. Gans, A. Galazyuk, and J. Wenstrup Intracellular Recordings From Combination-Sensitive Neurons in the Inferior Colliculus J Neurophysiol, August 1, 2008; 100(2): 629 - 645. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Bendor and X. Wang Neural Response Properties of Primary, Rostral, and Rostrotemporal Core Fields in the Auditory Cortex of Marmoset Monkeys J Neurophysiol, August 1, 2008; 100(2): 888 - 906. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Sadagopan and X. Wang Level Invariant Representation of Sounds by Populations of Neurons in Primary Auditory Cortex J. Neurosci., March 26, 2008; 28(13): 3415 - 3426. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. B. Christianson, M. Sahani, and J. F. Linden The Consequences of Response Nonlinearities for Interpretation of Spectrotemporal Receptive Fields J. Neurosci., January 9, 2008; 28(2): 446 - 455. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Moshitch, L. Las, N. Ulanovsky, O. Bar-Yosef, and I. Nelken Responses of Neurons in Primary Auditory Cortex (A1) to Pure Tones in the Halothane-Anesthetized Cat J Neurophysiol, June 1, 2006; 95(6): 3756 - 3769. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Nataraj and J. J. Wenstrup Roles of Inhibition in Complex Auditory Responses in the Inferior Colliculus: Inhibited Combination-Sensitive Neurons J Neurophysiol, April 1, 2006; 95(4): 2179 - 2192. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Marsh, K. Nataraj, D. Gans, C. V. Portfors, and J. J. Wenstrup Auditory Responses in the Cochlear Nucleus of Awake Mustached Bats: Precursors to Spectral Integration in the Auditory Midbrain J Neurophysiol, January 1, 2006; 95(1): 88 - 105. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. N. O'Connor, C. I. Petkov, and M. L. Sutter Adaptive Stimulus Optimization for Auditory Cortical Neurons J Neurophysiol, December 1, 2005; 94(6): 4051 - 4067. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. F. Chang, S. Bao, K. Imaizumi, C. E. Schreiner, and M. M. Merzenich Development of spectral and temporal response selectivity in the auditory cortex PNAS, November 8, 2005; 102(45): 16460 - 16465. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Eliades and X. Wang Dynamics of Auditory-Vocal Interaction in Monkey Auditory Cortex Cereb Cortex, October 1, 2005; 15(10): 1510 - 1523. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Qin, M. Sakai, S. Chimoto, and Y. Sato Interaction of Excitatory and Inhibitory Frequency-receptive Fields in Determining Fundamental Frequency Sensitivity of Primary Auditory Cortex Neurons in Awake Cats Cereb Cortex, September 1, 2005; 15(9): 1371 - 1383. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. L. Bartlett and X. Wang Long-Lasting Modulation by Stimulus Context in Primate Auditory Cortex J Neurophysiol, July 1, 2005; 94(1): 83 - 104. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Rauschecker and B. Tian Processing of Band-Passed Noise in the Lateral Auditory Belt Cortex of the Rhesus Monkey J Neurophysiol, June 1, 2004; 91(6): 2578 - 2589. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Eliades and X. Wang Sensory-Motor Interaction in the Primate Auditory Cortex During Self-Initiated Vocalizations J Neurophysiol, April 1, 2003; 89(4): 2194 - 2207. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
