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The Journal of Neurophysiology Vol. 85 No. 2 February 2001, pp. 620-629
Copyright ©2001 by the American Physiological Society
Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461
Peinado, Alejandro
Immature Neocortical Neurons Exist as Extensive Syncitial
Networks Linked by Dendrodendritic Electrical Connections. J. Neurophysiol. 85: 620-629, 2001. The
properties of immature cortex that may enable it to exhibit large-scale
wavelike activity during a brief critical developmental period were
investigated by imaging neuronal calcium signals in neonatal cortical
slices under conditions of artificially enhanced excitability,
conditions that produce a more frequent and robust version of the
naturally occurring waves. Using pharmacological manipulation to probe
the underlying mechanisms, I show that waves can propagate effectively
when excitatory synaptic transmission is blocked. In contrast,
propagation is very sensitive to reductions in gap junctional
communication. In the barrel field cortex wave propagation is affected
by the underlying cytoarchitecture in a way that is consistent with a
role for dendrodendritic gap junctions. The ability of cortex to
sustain wave activity ends around postnatal day 12, precisely when a major reduction in neuronal gap junctions takes place
in cortex. These results suggest that in immature cortex gap junctions
link neurons into extensive networks that may allow electrical activity
to spread over long distances.
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