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The Journal of Neurophysiology Vol. 79 No. 3 March 1998,
pp. 1349-1359
Copyright ©1998 The American Physiological Society
1 Whitney Laboratory, 2 Department of Zoology, and 3 Department of Neuroscience, University of Florida, St. Augustine, Florida 32086-8623
Zhainazarov, Aslbek B., Richard E. Doolin, and Barry W. Ache. Sodium-gated cation channel implicated in the activation of lobster olfactory receptor neurons. J. Neurophysiol. 79: 1349-1359, 1998. The role of Na+-activated channels in cellular function, if any, is still elusive. We have attempted to implicate a Na+-activated nonselective cation channel in the activation of lobster olfactory receptor neurons. We show that a Na+-activated channel occurs in the odor-detecting outer dendrites. With the use of pharmacological blockers of the channel together with ion substitution, we show that a substantial part of the odor-evoked depolarization in these cells can be ascribed to a Na+-activated conductance. We hypothesize, therefore, that the Na+-activated channel amplifies the receptor current as a result of being secondarily activated by the primary odor transduction pathway.
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A. B. Zhainazarov, R. Doolin, J.-D. Herlihy, and B. W. Ache Odor-Stimulated Phosphatidylinositol 3-Kinase in Lobster Olfactory Receptor Cells J Neurophysiol, June 1, 2001; 85(6): 2537 - 2544. [Abstract] [Full Text] [PDF]
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 A. B. Zhainazarov and B. W. Ache Effects of Phosphatidylinositol 4,5-Bisphosphate and Phosphatidylinositol 4-Phosphate on a Na+-Gated Nonselective Cation Channel J. Neurosci., April 15, 1999; 19(8): 2929 - 2937. [Abstract] [Full Text] [PDF]
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A. B. Zhainazarov and B. W. Ache Na+-Gated Nonselective Cation Channel From Lobster Olfactory Projection Neurons J Neurophysiol, December 1, 1998; 80(6): 3387 - 3391. [Abstract] [Full Text] [PDF]
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