JN Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 79: 555-566, 1998;
0022-3077/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Vicini, S.
Right arrow Articles by Grayson, D. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Vicini, S.
Right arrow Articles by Grayson, D. R.

The Journal of Neurophysiology Vol. 79 No. 2 February 1998, pp. 555-566
Copyright ©1998 The American Physiological Society

Functional and Pharmacological Differences Between Recombinant N-Methyl-D-Aspartate Receptors

Stefano Vicini1, Jian Feng Wang1, Jin Hong Li1, Wei Jian Zhu1, Yue Hua Wang2, JIAN HONG Luo2, Barry B. Wolfe2, and Dennis R. Grayson3

1 Department of Physiology and Biophysics and 2 Department of Pharmacology, Georgetown University School of Medicine, Washington, DC 20007; and 3 Departments of Psychiatry and Anatomy and Neurobiology, Neurosciences Research Center, Allegheny Singer Research Institute, Allegheny University of the Health Sciences, Pittsburgh, Pennsylvania 15212

Vicini, Stefano, Jian Feng Wang, Jin Hong Li, Wei Jian Zhu, Yue Hua Wang, Jian Hong Luo, Barry B. Wolfe, and Dennis R. Grayson. Functional and pharmacological differences between recombinant N-methyl-D-aspartate receptors. J. Neurophysiol. 79: 555-566, 1998. N-methyl-D-aspartic acid (NMDA) receptors transiently transfected into mammalian HEK-293 cells were characterized with subunit-specific antibodies and electrophysiological recordings. Deactivation time course recorded in response to fastL-glutamate pulses were studied in isolated and lifted cells, as well as in outside-out membrane patches excised from cells expressing recombinant NR1 subunits in combination with the NR2A, NR2B, NR2C, or NR2D NMDA receptor subunits. Transfected cells were preidentified by the fluorescence emitted from the coexpressed Aequorea victoria jellyfish Green Lantern protein. Currents generated by NR1/NR2A channels displayed double exponential deactivation time course being faster than that in NR1/NR2B or NR1/NR2C channels. However, a large decay variability was observed within each cotransfection, suggesting that mechanisms additional to subunit composition may also regulate deactivation time course. NR1/NR2D channels displayed slowly deactivating currents. Channel deactivation was fast and comparable among receptors obtained by cotransfecting five distinct spliced variants of the NR1 subunit, each with the NR2A subunit. Additionally, recovery from desensitization was slower for NR1/NR2B than for NR1/NR2A channels. The average deactivation time course of responses to brief L-glutamate applications in cells where NR1/NR2A/NR2B cDNAs were cotransfected at variable ratio was intermediate between those of the NR1/NR2A and NR1/NR2B channels. Although immunocytochemical evidence indicates that the majority of cells are cotransfected by all plasmids in triple transfection, our experimental condition did not allow for a tight control of the expression of NMDA receptor subunits. This produced the result that many cells were characterized by deactivation time course and haloperidol sensitivities of separate NR1/NR2A and NR1/NR2B subunit heteromers. We also speculate on the possible formation of channels resulting from the coassembly in the same receptor of NR1/NR2A/NR2B subunits from a minority of cells that gave responses to brief application of L-glutamate characterized by slow deactivation time course and decreased haloperidol sensitivity.




This article has been cited by other articles:


Home page
 J. Neurosci.Home page
S. C. Harney, D. E. Jane, and R. Anwyl
Extrasynaptic NR2D-Containing NMDARs Are Recruited to the Synapse during LTP of NMDAR-EPSCs
J. Neurosci., November 5, 2008; 28(45): 11685 - 11694.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
H. Khosravani, Y. Zhang, S. Tsutsui, S. Hameed, C. Altier, J. Hamid, L. Chen, M. Villemaire, Z. Ali, F. R. Jirik, et al.
Prion protein attenuates excitotoxicity by inhibiting NMDA receptors
J. Cell Biol., October 14, 2008; 181(3): 551 - 565.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. de Marchena, A. C. Roberts, P. G. Middlebrooks, V. Valakh, K. Yashiro, L. R. Wilfley, and B. D. Philpot
NMDA Receptor Antagonists Reveal Age-Dependent Differences in the Properties of Visual Cortical Plasticity
J Neurophysiol, October 1, 2008; 100(4): 1936 - 1948.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
S. M. Dravid, A. Prakash, and S. F. Traynelis
Activation of recombinant NR1/NR2C NMDA receptors
J. Physiol., September 15, 2008; 586(18): 4425 - 4439.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. S. Grubb, A. Nissant, K. Murray, and P.-M. Lledo
Functional Maturation of the First Synapse in Olfaction: Development and Adult Neurogenesis
J. Neurosci., March 12, 2008; 28(11): 2919 - 2932.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
D. J. A. Wyllie
2B or 2B and 2D? - That is the question
J. Physiol., February 1, 2008; 586(3): 693 - 693.
[Full Text] [PDF]

Home page
 J. Physiol.Home page
S. L. C. Brothwell, J. L. Barber, D. T. Monaghan, D. E. Jane, A. J. Gibb, and S. Jones
NR2B- and NR2D-containing synaptic NMDA receptors in developing rat substantia nigra pars compacta dopaminergic neurones
J. Physiol., February 1, 2008; 586(3): 739 - 750.
[Abstract] [Full Text] [PDF]

Home page
 Learn. Mem.Home page
D. L. Walker and M. Davis
Amygdala infusions of an NR2B-selective or an NR2A-preferring NMDA receptor antagonist differentially influence fear conditioning and expression in the fear-potentiated startle test
Learn. Mem., January 28, 2008; 15(2): 67 - 74.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
R. C. Ewald, K. R. Van Keuren-Jensen, C. D. Aizenman, and H. T. Cline
Roles of NR2A and NR2B in the Development of Dendritic Arbor Morphology In Vivo
J. Neurosci., January 23, 2008; 28(4): 850 - 861.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
L. Medrihan, E. Tantalaki, G. Aramuni, V. Sargsyan, I. Dudanova, M. Missler, and W. Zhang
Early Defects of GABAergic Synapses in the Brain Stem of a MeCP2 Mouse Model of Rett Syndrome
J Neurophysiol, January 1, 2008; 99(1): 112 - 121.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
D. C. Wrighton, E. J. Baker, P. E. Chen, and D. J. A. Wyllie
Mg2+ and memantine block of rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytes
J. Physiol., January 1, 2008; 586(1): 211 - 225.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
P. E. Chen, M. T. Geballe, E. Katz, K. Erreger, M. R. Livesey, K. K. O'Toole, P. Le, C. J. Lee, J. P. Snyder, S. F. Traynelis, et al.
Modulation of glycine potency in rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytes
J. Physiol., January 1, 2008; 586(1): 227 - 245.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
A. J. Milnerwood and L. A. Raymond
Corticostriatal synaptic function in mouse models of Huntington's disease: early effects of huntingtin repeat length and protein load
J. Physiol., December 15, 2007; 585(3): 817 - 831.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
B. J. Hall, B. Ripley, and A. Ghosh
NR2B Signaling Regulates the Development of Synaptic AMPA Receptor Current
J. Neurosci., December 5, 2007; 27(49): 13446 - 13456.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
M. Renzi, M. Farrant, and S. G. Cull-Candy
Climbing-fibre activation of NMDA receptors in Purkinje cells of adult mice
J. Physiol., November 15, 2007; 585(1): 91 - 101.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
S. M. Logan, J. G. Partridge, J. A. Matta, A. Buonanno, and S. Vicini
Long-Lasting NMDA Receptor-Mediated EPSCs in Mouse Striatal Medium Spiny Neurons
J Neurophysiol, November 1, 2007; 98(5): 2693 - 2704.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. Ding, T. Fellin, Y. Zhu, S.-Y. Lee, Y. P. Auberson, D. F. Meaney, D. A. Coulter, G. Carmignoto, and P. G. Haydon
Enhanced Astrocytic Ca2+ Signals Contribute to Neuronal Excitotoxicity after Status Epilepticus
J. Neurosci., October 3, 2007; 27(40): 10674 - 10684.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
K. Erreger, M. T. Geballe, A. Kristensen, P. E. Chen, K. B. Hansen, C. J. Lee, H. Yuan, P. Le, P. N. Lyuboslavsky, N. Micale, et al.
Subunit-Specific Agonist Activity at NR2A-, NR2B-, NR2C-, and NR2D-Containing N-Methyl-D-aspartate Glutamate Receptors
Mol. Pharmacol., October 1, 2007; 72(4): 907 - 920.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. Kourrich, P. E. Rothwell, J. R. Klug, and M. J. Thomas
Cocaine Experience Controls Bidirectional Synaptic Plasticity in the Nucleus Accumbens
J. Neurosci., July 25, 2007; 27(30): 7921 - 7928.
[Abstract] [Full Text] [PDF]

Home page
 JGPHome page
A. I. Sobolevsky, M. L. Prodromou, M. V. Yelshansky, and L. P. Wollmuth
Subunit-specific Contribution of Pore-forming Domains to NMDA Receptor Channel Structure and Gating
J. Gen. Physiol., June 1, 2007; 129(6): 509 - 525.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. C. Gerkin, P.-M. Lau, D. W. Nauen, Y. T. Wang, and G.-Q. Bi
Modular Competition Driven by NMDA Receptor Subtypes in Spike-Timing-Dependent Plasticity
J Neurophysiol, April 1, 2007; 97(4): 2851 - 2862.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. D'Ascenzo, T. Fellin, M. Terunuma, R. Revilla-Sanchez, D. F. Meaney, Y. P. Auberson, S. J. Moss, and P. G. Haydon
mGluR5 stimulates gliotransmission in the nucleus accumbens
PNAS, February 6, 2007; 104(6): 1995 - 2000.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J.-C. Beique, D.-T. Lin, M.-G. Kang, H. Aizawa, K. Takamiya, and R. L. Huganir
Synapse-specific regulation of AMPA receptor function by PSD-95
PNAS, December 19, 2006; 103(51): 19535 - 19540.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
C. Lu, Z. Fu, I. Karavanov, R. P. Yasuda, B. B. Wolfe, A. Buonanno, and S. Vicini
NMDA Receptor Subtypes at Autaptic Synapses of Cerebellar Granule Neurons
J Neurophysiol, November 1, 2006; 96(5): 2282 - 2294.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
C. M. Norris, E. M. Blalock, O. Thibault, L. D. Brewer, G. V. Clodfelter, N. M. Porter, and P. W. Landfield
Electrophysiological Mechanisms of Delayed Excitotoxicity: Positive Feedback Loop Between NMDA Receptor Current and Depolarization-Mediated Glutamate Release
J Neurophysiol, November 1, 2006; 96(5): 2488 - 2500.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
P. A. Frizelle, P. E. Chen, and D. J. A. Wyllie
Equilibrium Constants for (R)-[(S)-1-(4-Bromo-phenyl)-ethylamino]-(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-methyl]-phosphonic Acid (NVP-AAM077) Acting at Recombinant NR1/NR2A and NR1/NR2B N-Methyl-D-aspartate Receptors: Implications for Studies of Synaptic Transmission
Mol. Pharmacol., September 1, 2006; 70(3): 1022 - 1032.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
B. Schilstrom, R. Yaka, E. Argilli, N. Suvarna, J. Schumann, B. T. Chen, M. Carman, V. Singh, W. S. Mailliard, D. Ron, et al.
Cocaine Enhances NMDA Receptor-Mediated Currents in Ventral Tegmental Area Cells via Dopamine D5 Receptor-Dependent Redistribution of NMDA Receptors.
J. Neurosci., August 15, 2006; 26(33): 8549 - 8558.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
D. J. A. Wyllie, A. R. Johnston, D. Lipscombe, and P. E. Chen
Single-channel analysis of a point mutation of a conserved serine residue in the S2 ligand-binding domain of the NR2A NMDA receptor subunit
J. Physiol., July 15, 2006; 574(2): 477 - 489.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
P. G. Haydon and G. Carmignoto
Astrocyte control of synaptic transmission and neurovascular coupling.
Physiol Rev, July 1, 2006; 86(3): 1009 - 1031.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
Y. Dan and M.-M. Poo
Spike timing-dependent plasticity: from synapse to perception.
Physiol Rev, July 1, 2006; 86(3): 1033 - 1048.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B.-S. Chen, S. Braud, J. D. Badger II, J. T. R. Isaac, and K. W. Roche
Regulation of NR1/NR2C N-Methyl-D-aspartate (NMDA) Receptors by Phosphorylation
J. Biol. Chem., June 16, 2006; 281(24): 16583 - 16590.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
R. J. Clarke and J. W. Johnson
NMDA Receptor NR2 Subunit Dependence of the Slow Component of Magnesium Unblock
J. Neurosci., May 24, 2006; 26(21): 5825 - 5834.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
G. H. Son, D. Geum, S. Chung, E. J. Kim, J.-H. Jo, C.-M. Kim, K. H. Lee, H. Kim, S. Choi, H. T. Kim, et al.
Maternal stress produces learning deficits associated with impairment of NMDA receptor-mediated synaptic plasticity.
J. Neurosci., March 22, 2006; 26(12): 3309 - 3318.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
C. G. Thomas, A. J. Miller, and G. L. Westbrook
Synaptic and Extrasynaptic NMDA Receptor NR2 Subunits in Cultured Hippocampal Neurons
J Neurophysiol, March 1, 2006; 95(3): 1727 - 1734.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
S. Jones and A. J. Gibb
Functional NR2B- and NR2D-containing NMDA receptor channels in rat substantia nigra dopaminergic neurones
J. Physiol., November 15, 2005; 569(1): 209 - 221.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
G. Popescu
Principles of N-Methyl-D-aspartate Receptor Allosteric Modulation
Mol. Pharmacol., October 1, 2005; 68(4): 1148 - 1155.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
A. Auerbach and Y. Zhou
Gating Reaction Mechanisms for NMDA Receptor Channels
J. Neurosci., August 31, 2005; 25(35): 7914 - 7923.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
E. Y. Yuen, Q. Jiang, J. Feng, and Z. Yan
Microtubule Regulation of N-Methyl-D-aspartate Receptor Channels in Neurons
J. Biol. Chem., August 19, 2005; 280(33): 29420 - 29427.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
A. Dahlhaus, R. Ruscheweyh, and J. Sandkuhler
Synaptic input of rat spinal lamina I projection and unidentified neurones in vitro
J. Physiol., July 15, 2005; 566(2): 355 - 368.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. E. Calcagnotto and S. C. Baraban
Prolonged NMDA-Mediated Responses, Altered Ifenprodil Sensitivity, and Epileptiform-Like Events in the Malformed Hippocampus of Methylazoxymethanol Exposed Rats
J Neurophysiol, July 1, 2005; 94(1): 153 - 162.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. Sinagra, D. Verrier, D. Frankova, K. M. Korwek, J. Blahos, E. J. Weeber, O. J. Manzoni, and P. Chavis
Reelin, Very-Low-Density Lipoprotein Receptor, and Apolipoprotein E Receptor 2 Control Somatic NMDA Receptor Composition during Hippocampal Maturation In Vitro
J. Neurosci., June 29, 2005; 25(26): 6127 - 6136.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
E. Y. Yuen, Q. Jiang, P. Chen, Z. Gu, J. Feng, and Z. Yan
Serotonin 5-HT1A Receptors Regulate NMDA Receptor Channels through a Microtubule-Dependent Mechanism
J. Neurosci., June 8, 2005; 25(23): 5488 - 5501.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
P. E. Chen, M. T. Geballe, P. J. Stansfeld, A. R. Johnston, H. Yuan, A. L. Jacob, J. P. Snyder, S. F. Traynelis, and D. J. A. Wyllie
Structural Features of the Glutamate Binding Site in Recombinant NR1/NR2A N-Methyl-D-aspartate Receptors Determined by Site-Directed Mutagenesis and Molecular Modeling
Mol. Pharmacol., May 1, 2005; 67(5): 1470 - 1484.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
Z. Fu, S. M Logan, and S. Vicini
Deletion of the NR2A subunit prevents developmental changes of NMDA-mEPSCs in cultured mouse cerebellar granule neurones
J. Physiol., March 15, 2005; 563(3): 867 - 881.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
M. Martina, M.-E. B.-Turcotte, S. Halman, G. Tsai, M. Tiberi, J. T Coyle, and R. Bergeron
Reduced glycine transporter type 1 expression leads to major changes in glutamatergic neurotransmission of CA1 hippocampal neurones in mice
J. Physiol., March 15, 2005; 563(3): 777 - 793.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
K. Erreger, S. M Dravid, T. G Banke, D. J. A Wyllie, and S. F Traynelis
Subunit-specific gating controls rat NR1/NR2A and NR1/NR2B NMDA channel kinetics and synaptic signalling profiles
J. Physiol., March 1, 2005; 563(2): 345 - 358.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
A. Qian, A. L. Buller, and J. W. Johnson
NR2 subunit-dependence of NMDA receptor channel block by external Mg2+
J. Physiol., January 15, 2005; 562(2): 319 - 331.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. Townsend, Y. Liu, and M. Constantine-Paton
Retina-Driven Dephosphorylation of the NR2A Subunit Correlates with Faster NMDA Receptor Kinetics at Developing Retinocollicular Synapses
J. Neurosci., December 8, 2004; 24(49): 11098 - 11107.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
L. Li, T. H. Murphy, M. R. Hayden, and L. A. Raymond
Enhanced Striatal NR2B-Containing N-Methyl-D-Aspartate Receptor-Mediated Synaptic Currents in a Mouse Model of Huntington Disease
J Neurophysiol, November 1, 2004; 92(5): 2738 - 2746.
[Abstract] [Full Text] [PDF]

Home page
 Sci SignalHome page
S. G. Cull-Candy and D. N. Leszkiewicz
Role of Distinct NMDA Receptor Subtypes at Central Synapses
Sci. Signal., October 19, 2004; 2004(255): re16 - re16.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
N. A. Lozovaya, S. E. Grebenyuk, T. Sh. Tsintsadze, B. Feng, D. T. Monaghan, and O. A. Krishtal
Extrasynaptic NR2B and NR2D subunits of NMDA receptors shape 'superslow' afterburst EPSC in rat hippocampus
J. Physiol., July 15, 2004; 558(2): 451 - 463.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
G. Lavezzari, J. McCallum, C. M. Dewey, and K. W. Roche
Subunit-Specific Regulation of NMDA Receptor Endocytosis
J. Neurosci., July 14, 2004; 24(28): 6383 - 6391.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
P. E. Chen, A. R. Johnston, M. H. S. Mok, R. Schoepfer, and D. J. A. Wyllie
Influence of a threonine residue in the S2 ligand binding domain in determining agonist potency and deactivation rate of recombinant NR1a/NR2D NMDA receptors
J. Physiol., July 1, 2004; 558(1): 45 - 58.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
V. M. Andre, J. Flores-Hernandez, C. Cepeda, A. J. Starling, S. Nguyen, M. K. Lobo, H. V. Vinters, M. S. Levine, and G. W. Mathern
NMDA Receptor Alterations in Neurons from Pediatric Cortical Dysplasia Tissue
Cereb Cortex, June 1, 2004; 14(6): 634 - 646.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
L. Pei, F. J. S. Lee, A. Moszczynska, B. Vukusic, and F. Liu
Regulation of Dopamine D1 Receptor Function by Physical Interaction with the NMDA Receptors
J. Neurosci., February 4, 2004; 24(5): 1149 - 1158.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
J. P. Tyszkiewicz, Z. Gu, X. Wang, X. Cai, and Z. Yan
Group II metabotropic glutamate receptors enhance NMDA receptor currents via a protein kinase C-dependent mechanism in pyramidal neurones of rat prefrontal cortex
J. Physiol., February 1, 2004; 554(3): 765 - 777.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
Z. Fu, P. Washbourne, P. Ortinski, and S. Vicini
Functional Excitatory Synapses in HEK293 Cells Expressing Neuroligin and Glutamate Receptors
J Neurophysiol, December 1, 2003; 90(6): 3950 - 3957.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. S. Kumar and J. R. Huguenard
Pathway-Specific Differences in Subunit Composition of Synaptic NMDA Receptors on Pyramidal Neurons in Neocortex
J. Neurosci., November 5, 2003; 23(31): 10074 - 10083.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
N. O. Dalby and I. Mody
Activation of NMDA Receptors in Rat Dentate Gyrus Granule Cells by Spontaneous and Evoked Transmitter Release
J Neurophysiol, August 1, 2003; 90(2): 786 - 797.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. Lopez de Armentia and P. Sah
Development and Subunit Composition of Synaptic NMDA Receptors in the Amygdala: NR2B Synapses in the Adult Central Amygdala
J. Neurosci., July 30, 2003; 23(17): 6876 - 6883.
[Abstract]