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J Neurophysiol 79: 137-142, 1998;
0022-3077/98 $5.00
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The Journal of Neurophysiology Vol. 79 No. 1 January 1998, pp. 137-142
Copyright ©1998 The American Physiological Society

Abnormal Synaptic Transmission in the Olfactory Bulb of Fyn-Kinase-Deficient Mice

Hiromasa Kitazawa1, Takeshi Yagi2, Tsuyoshi Miyakawa3, Hiroaki Niki3, and Nobufumi Kawai1

1 Department of Physiology, Jichi Medical School, Tochigi 329-04; 2 Laboratory of Neurobiology and Behavioral Genetics, National Institute for Physiology, Okazaki 444; and 3 Laboratory for Neurobiology of Emotion, Brain Science Institute, RIKEN, Hiroasawa, Wakoshi, Saitama 351-01, Japan

Kitazawa, Hiromasa, Takeshi Yagi, Tsuyoshi Miyakawa, Hiroaki Niki, and Nobufumi Kawai. Abnormal synaptic transmission in the olfactory bulb of Fyn-kinase-deficient mice. J. Neurophysiol. 79: 137-142, 1998. We studied synaptic transmission in the granule cells in the olfactory bulb of the homozygous Fyn (a nonreceptor type tyrosine kinase)-deficient (fynz/fynz) and heterozygous Fyn-deficient (+/fynz) mice by using slice preparations from the olfactory bulb. Stimulation to the lateral olfactory tract and/or centrifugal fibers to the olfactory bulb evoked field excitatory postsynaptic potentials (fEPSPs) in the granule cells. In +/fynz mice, fEPSPs were augmented by bicuculline, a gamma -aminobutyric acid (GABAA) antagonist and picrotoxin, whereas fEPSPs in fynz/fynz mice were much less sensitive to bicuculline and picrotoxin. Application of D-2-amino-5-phosphonopentanoic acid had no effect but 6-cyano-7-nitroquinoxaline-2,3-dione produced almost complete block of fEPSPs in both +/fynz mice and fynz/fynz mice. (1S, 3R)-1-aminocyclo-pentane-1.3-dicarboxylate, an agonist of metabotropic glutamate receptors caused a similar depression of fEPSPs in both +/fynz and fynz/fynz mice. In +/fynz mice tetanic stimulation to the lateral olfactory tract and/or centrifugal fibers induced N-methyl-D-aspartate (NMDA)-dependent long-term potentiation (LTP) of fEPSPs, whereas LTP was impaired in fynz/fynz mice. Our results demonstrate altered functions of GABAA and NMDA receptors in the olfactory system of Fyn-deficient mice.




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