JN Miami Valley Hospital
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 75: 2662-2670, 1996;
0022-3077/96 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tommerdahl, M.
Right arrow Articles by Whitsel, B. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tommerdahl, M.
Right arrow Articles by Whitsel, B. L.

Journal of Neurophysiology, Vol 75, Issue 6 2662-2670, Copyright © 1996 by APS

ARTICLES

Anterior parietal cortical response to tactile and skin-heating stimuli applied to the same skin site

M. Tommerdahl, K. A. Delemos, C. J. Vierck Jr, O. V. Favorov and B. L. Whitsel
Department of Biomedical Engineering, University of North Carolina at Chapel Hill 27599, USA.

1. The response of anterior parietal cortex to skin stimuli was evaluated with optical intrinsic signal imaging and extracellular microelectrode recording methods in anesthetized squirrel monkeys. 2. Nonnoxious mechanical stimulation (vibrotactile or skin tapping) of the contralateral radial interdigital pad was accompanied by a decrease in reflectance (at 833 nm) in sectors of cytoarchitectonic areas 3b and 1. This intrinsic signal was in register with regions shown by previous receptive field mapping studies to receive low-threshold mechanoreceptor input from the radial interdigital pad. 3. A skin-heating stimulus applied to the contralateral radial interdigital pad with a stationary probe/thermode evoked no discernable intrinsic signal in areas 3b and 1, but evoked a signal within a circumscribed part of area 3a. The region of area 3a responsive to skin heating with the stationary probe/thermode was adjacent to the areas 3b and 1 regions that developed an intrinsic signal in response to vibrotactile stimulation of the same skin site. Skin heating with a stationary probe/thermode also evoked intrinsic signal in regions of areas 4 and 2 neighboring the area 3b/1 regions activated by vibrotactile stimulation of the contralateral radial interdigital pad. 4. The intrinsic signal evoked in area 3a by a series of heating stimuli to the contralateral radial interdigital pad (applied with a stationary probe/thermode) increased progressively in magnitude with repeated stimulation (exhibited slow temporal summation) and remained above prestimulus levels for a prolonged period after termination of repetitive stimulation. 5. Brief mechanical stimuli ("taps") applied to the contralateral radial interdigital pad with a probe/thermode maintained either at 37 degrees C or at 52 degrees C were accompanied by the development of an intrinsic signal in both area 3a and areas 3b/1. For the 52 degrees C stimulus, the area 3a intrinsic signal was larger and the intrinsic signal in areas 3b/1 smaller than the corresponding signals evoked by the 37 degrees C stimulus. 6. Spike discharge activity was recorded from area 3a neurons during a repetitive heating stimulus applied with a stationary probe/ thermode to the contralateral radial interdigital pad. Like the area 3a intrinsic signal elicited by repetitive heating of the same skin site, the area 3a neuron spike discharge activity also exhibited slow temporal summation and poststimulus response persistence. 7. The experimental findings suggest 1) a leading role for area 3a in the anterior parietal cortical processing of skin-heating stimuli, and 2) the presence of inhibitory interactions between the anterior parietal responses to painful and vibrotactile stimuli consistent with those demonstrated in recent cortical imaging and psychophysical studies of human subjects.


This article has been cited by other articles:


Home page
 Cereb CortexHome page
B. L. Whitsel, O. V. Favorov, Y. Li, M. Quibrera, and M. Tommerdahl
Area 3a Neuron Response to Skin Nociceptor Afferent Drive
Cereb Cortex, June 4, 2008; (2008) bhn086v1.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
B. Fromy, D. Sigaudo-Roussel, C. Baron, Y. Roquelaure, G. Leftheriotis, and J. L. Saumet
Neuroendocrine pathway involvement in the loss of the cutaneous pressure-induced vasodilatation during acute pain in rats
J. Physiol., February 15, 2007; 579(1): 247 - 254.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
L. Monconduit, A. Lopez-Avila, J.-L. Molat, M. Chalus, and L. Villanueva
Corticofugal Output from the Primary Somatosensory Cortex Selectively Modulates Innocuous and Noxious Inputs in the Rat Spinothalamic System.
J. Neurosci., August 15, 2006; 26(33): 8441 - 8450.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
K. Inui, T. Tsuji, and R. Kakigi
Temporal Analysis of Cortical Mechanisms for Pain Relief by Tactile Stimuli in Humans
Cereb Cortex, March 1, 2006; 16(3): 355 - 365.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
E. A. Moulton, M. L. Keaser, R. P. Gullapalli, and J. D. Greenspan
Regional Intensive and Temporal Patterns of Functional MRI Activation Distinguishing Noxious and Innocuous Contact Heat
J Neurophysiol, April 1, 2005; 93(4): 2183 - 2193.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. D. Craig
Lamina I, but not Lamina V, Spinothalamic Neurons Exhibit Responses That Correspond With Burning Pain
J Neurophysiol, October 1, 2004; 92(4): 2604 - 2609.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. Ploner, B. Pollok, and A. Schnitzler
Pain Facilitates Tactile Processing in Human Somatosensory Cortices
J Neurophysiol, September 1, 2004; 92(3): 1825 - 1829.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
S. Ohara, N. E. Crone, N. Weiss, R.-D. Treede, and F. A. Lenz
Cutaneous Painful Laser Stimuli Evoke Responses Recorded Directly From Primary Somatosensory Cortex in Awake Humans
J Neurophysiol, June 1, 2004; 91(6): 2734 - 2746.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
S.-I. Ito and A. D. Craig
Vagal Input to Lateral Area 3a in Cat Cortex
J Neurophysiol, July 1, 2003; 90(1): 143 - 154.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
S Gilman
Joint position sense and vibration sense: anatomical organisation and assessment
J. Neurol. Neurosurg. Psychiatry, November 1, 2002; 73(5): 473 - 477.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Interv.Home page
D. D. Price
Central Neural Mechanisms that Interrelate Sensory and Affective Dimensions of Pain
Mol. Interv., October 1, 2002; 2(6): 392 - 403.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J.-I Chen, B. Ha, M. C. Bushnell, B. Pike, and G. H. Duncan
Differentiating Noxious- and Innocuous-Related Activation of Human Somatosensory Cortices Using Temporal Analysis of fMRI
J Neurophysiol, July 1, 2002; 88(1): 464 - 474.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. D. Craig and D. Andrew
Responses of Spinothalamic Lamina I Neurons to Repeated Brief Contact Heat Stimulation in the Cat
J Neurophysiol, April 1, 2002; 87(4): 1902 - 1914.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
K. J. Huffman and L. Krubitzer
Area 3a: Topographic Organization and Cortical Connections in Marmoset Monkeys
Cereb Cortex, September 1, 2001; 11(9): 849 - 867.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. Shoham and A. Grinvald
The Cortical Representation of the Hand in Macaque and Human Area S-I: High Resolution Optical Imaging
J. Neurosci., September 1, 2001; 21(17): 6820 - 6835.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
D. R. Kenshalo, K. Iwata, M. Sholas, and D. A. Thomas
Response Properties and Organization of Nociceptive Neurons in Area 1 of Monkey Primary Somatosensory Cortex
J Neurophysiol, August 1, 2000; 84(2): 719 - 729.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
C. I. Moore, C. E. Stern, S. Corkin, B. Fischl, A. C. Gray, B. R. Rosen, and A. M. Dale
Segregation of Somatosensory Activation in the Human Rolandic Cortex Using fMRI
J Neurophysiol, July 1, 2000; 84(1): 558 - 569.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. C. Bushnell, G. H. Duncan, R. K. Hofbauer, B. Ha, J.-I. Chen, and B. Carrier
Pain perception: Is there a role for primary somatosensory cortex?
PNAS, July 6, 1999; 96(14): 7705 - 7709.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. Tommerdahl, K. A. Delemos, B. L. Whitsel, O. V. Favorov, and C. B. Metz
Response of Anterior Parietal Cortex to Cutaneous Flutter Versus Vibration
J Neurophysiol, July 1, 1999; 82(1): 16 - 33.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. Tommerdahl, K. A. Delemos, O. V. Favorov, C. B. Metz, C. J. Vierck Jr., and B. L. Whitsel
Response of Anterior Parietal Cortex to Different Modes of Same-Site Skin Stimulation
J Neurophysiol, December 1, 1998; 80(6): 3272 - 3283.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. W. Dykes and A. D. Craig
Control of Size and Excitability of Mechanosensory Receptive Fields in Dorsal Column Nuclei by Homolateral Dorsal Horn Neurons
J Neurophysiol, July 1, 1998; 80(1): 120 - 129.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
C. J. Vierck Jr., R. L. Cannon, G. Fry, W. Maixner, and B. L. Whitsel
Characteristics of Temporal Summation of Second Pain Sensations Elicited by Brief Contact of Glabrous Skin by a Preheated Thermode
J Neurophysiol, August 1, 1997; 78(2): 992 - 1002.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online