JN Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 75: 2157-2160, 1996;
0022-3077/96 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Neveu, D.
Right arrow Articles by Zucker, R. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Neveu, D.
Right arrow Articles by Zucker, R. S.

Journal of Neurophysiology, Vol 75, Issue 5 2157-2160, Copyright © 1996 by APS

ARTICLES

Long-lasting potentiation and depression without presynaptic activity

D. Neveu and R. S. Zucker
Neurobiology Division, University of California, Berkeley 94720, USA.

1. Long-term potentiation (LTP) and long-term depression (LTD) require a rise in intracellular Ca2+ concentration ([Ca2+]i) in the postsynaptic CA1 pyramidal neuron to activate Ca-dependent biochemical processes. This rise in [Ca2+]i is a necessary trigger for the induction of LTP and LTD, but it is unclear if concurrent presynaptic activity is required for their induction or expression. 2. We used photolysis of the caged-Ca2+ compound nitr-5 to elevate postsynaptic [Ca2+]i. Long-lasting potentiation (LLP) and long-lasting depression (LLD) were obtained in the absence of presynaptic activity. 3. Because LLP and LLD share common features with LTP and LTD induced by presynaptic stimulation these results show that a rise in [Ca2+]i in the postsynaptic CA1 pyramidal neurons is necessary and sufficient for the induction and expression of LTP and LTD, and that concurrent presynaptic activity is not required.


This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
K. B. Grey and B. D. Burrell
Forskolin Induces NMDA Receptor-Dependent Potentiation at a Central Synapse in the Leech
J Neurophysiol, May 1, 2008; 99(5): 2719 - 2724.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
N. Otmakhov, L. Khibnik, N. Otmakhova, S. Carpenter, S. Riahi, B. Asrican, and J. Lisman
Forskolin-Induced LTP in the CA1 Hippocampal Region Is NMDA Receptor Dependent
J Neurophysiol, May 1, 2004; 91(5): 1955 - 1962.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. C. Oakley, P. C. Schwindt, and W. E. Crill
Initiation and Propagation of Regenerative Ca2+-Dependent Potentials in Dendrites of Layer 5 Pyramidal Neurons
J Neurophysiol, July 1, 2001; 86(1): 503 - 513.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
D. Le Ray and D. Cattaert
Active Motor Neurons Potentiate Their Own Sensory Inputs via Glutamate-Induced Long-Term Potentiation
J. Neurosci., February 15, 1999; 19(4): 1473 - 1483.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
S.-N. Yang, Y.-G. Tang, and R. S. Zucker
Selective Induction of LTP and LTD by Postsynaptic [Ca2+]i Elevation
J Neurophysiol, February 1, 1999; 81(2): 781 - 787.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online