JN AJP: Heart and Circulatory Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 75: 1806-1814, 1996;
0022-3077/96 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Holt, G. R.
Right arrow Articles by Douglas, R. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Holt, G. R.
Right arrow Articles by Douglas, R. J.

Journal of Neurophysiology, Vol 75, Issue 5 1806-1814, Copyright © 1996 by APS

ARTICLES

Comparison of discharge variability in vitro and in vivo in cat visual cortex neurons

G. R. Holt, W. R. Softky, C. Koch and R. J. Douglas
Computation and Neural Systems Program, California Institute of Technology, Pasadena 91125, USA.

1. In neocortical slices, the majority of neurons fire quite regularly in response to constant current injections. But neurons in the intact animal fire irregularly in response to constant current injection as well as to visual stimuli. 2. To quantify this observation, we developed a new measure of variability, which compares only adjacent interspike intervals and is therefore less sensitive to rate variations than existing measures such as the coefficient of variation of interspike intervals. 3. We find that the variability of firing is much higher in cells of primary visual cortex in the anesthetized cat than in slice. The response to current injected from an intracellular electrode in vivo is also variable, but slightly more regular and less bursty than in response to visual stimuli. 4. Using a new technique for analyzing the variability of integrate-and-fire neurons, we prove that this behavior is consistent with a simple integrate-and-fire model receiving a large amount of synaptic background activity, but not with a noisy spiking mechanism.


This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
J. F. M. van Brederode and A. J. Berger
Spike-Firing Resonance in Hypoglossal Motoneurons
J Neurophysiol, June 1, 2008; 99(6): 2916 - 2928.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
C. R. Butson and G. A. Clark
Random Noise Paradoxically Improves Light-Intensity Encoding in Hermissenda Photoreceptor Network
J Neurophysiol, January 1, 2008; 99(1): 146 - 154.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
K. Miura, Y. Tsubo, M. Okada, and T. Fukai
Balanced Excitatory and Inhibitory Inputs to Cortical Neurons Decouple Firing Irregularity from Rate Modulations
J. Neurosci., December 12, 2007; 27(50): 13802 - 13812.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. J. Birdno, S. E. Cooper, A. R. Rezai, and W. M. Grill
Pulse-to-Pulse Changes in the Frequency of Deep Brain Stimulation Affect Tremor and Modeled Neuronal Activity
J Neurophysiol, September 1, 2007; 98(3): 1675 - 1684.
[Abstract] [Full Text] [PDF]

Home page
 Neural Comput.Home page
P. Rowat
Interspike Interval Statistics in the Stochastic Hodgkin-Huxley Model: Coexistence of Gamma Frequency Bursts and Highly Irregular Firing
Neural Comput., May 1, 2007; 19(5): 1215 - 1250.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
D. Durstewitz and T. Gabriel
Dynamical Basis of Irregular Spiking in NMDA-Driven Prefrontal Cortex Neurons
Cereb Cortex, April 1, 2007; 17(4): 894 - 908.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
F. S. Chance
Receiver Operating Characteristic (ROC) Analysis for Characterizing Synaptic Efficacy
J Neurophysiol, February 1, 2007; 97(2): 1799 - 1808.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
G. La Camera, A. Rauch, D. Thurbon, H.-R. Luscher, W. Senn, and S. Fusi
Multiple Time Scales of Temporal Response in Pyramidal and Fast Spiking Cortical Neurons
J Neurophysiol, December 1, 2006; 96(6): 3448 - 3464.
[Abstract] [Full Text] [PDF]

Home page
 Neural Comput.Home page
K. Miura, M. Okada, and S.-i. Amari
Estimating Spiking Irregularities Under Changing Environments.
Neural Comput., October 1, 2006; 18(10): 2359 - 2386.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. M. Davies, G. L. Gerstein, and S. N. Baker
Measurement of Time-Dependent Changes in the Irregularity of Neural Spiking
J Neurophysiol, August 1, 2006; 96(2): 906 - 918.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
H. Homayoun and B. Moghaddam
Bursting of Prefrontal Cortex Neurons in Awake Rats is Regulated by Metabotropic Glutamate 5 (mGlu5) Receptors: Rate-dependent Influence and Interaction with NMDA Receptors
Cereb Cortex, January 1, 2006; 16(1): 93 - 105.
[Abstract] [Full Text] [PDF]

Home page
 Neural Comput.Home page
K. Ikeda
Information Geometry of Interspike Intervals in Spiking Neurons
Neural Comput., December 1, 2005; 17(12): 2719 - 2735.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. P. Vogels and L. F. Abbott
Signal Propagation and Logic Gating in Networks of Integrate-and-Fire Neurons
J. Neurosci., November 16, 2005; 25(46): 10786 - 10795.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. A. Henrie and R. Shapley
LFP Power Spectra in V1 Cortex: The Graded Effect of Stimulus Contrast
J Neurophysiol, July 1, 2005; 94(1): 479 - 490.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
S. Shinomoto, Y. Miyazaki, H. Tamura, and I. Fujita
Regional and Laminar Differences in In Vivo Firing Patterns of Primate Cortical Neurons
J Neurophysiol, July 1, 2005; 94(1): 567 - 575.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R. Schaette, T. Gollisch, and A. V. M. Herz
Spike-Train Variability of Auditory Neurons In Vivo: Dynamic Responses Follow Predictions From Constant Stimuli
J Neurophysiol, June 1, 2005; 93(6): 3270 - 3281.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
H. Oviedo and A. D. Reyes
Variation of Input-Output Properties along the Somatodendritic Axis of Pyramidal Neurons
J. Neurosci., May 18, 2005; 25(20): 4985 - 4995.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
H. Homayoun, M. E. Jackson, and B. Moghaddam
Activation of Metabotropic Glutamate 2/3 Receptors Reverses the Effects of NMDA Receptor Hypofunction on Prefrontal Cortex Unit Activity in Awake Rats
J Neurophysiol, April 1, 2005; 93(4): 1989 - 2001.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
M. E. Larkum, W. Senn, and H.-R. Luscher
Top-down Dendritic Input Increases the Gain of Layer 5 Pyramidal Neurons
Cereb Cortex, October 1, 2004; 14(10): 1059 - 1070.
[Abstract] [Full Text] [PDF]

Home page
 Neural Comput.Home page
S. Shinomoto, K. Shima, and J. Tanji
Differences in Spiking Patterns Among Cortical Neurons
Neural Comput., December 1, 2003; 15(12): 2823 - 2842.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. Compte,, C. Constantinidis, J. Tegner, S. Raghavachari, M. V. Chafee, P. S. Goldman-Rakic, and X.-J. Wang
Temporally Irregular Mnemonic Persistent Activity in Prefrontal Neurons of Monkeys During a Delayed Response Task
J Neurophysiol, November 1, 2003; 90(5): 3441 - 3454.
[Abstract] [Full Text] [PDF]

Home page
 Cereb CortexHome page
J.-M. Fellous and T. J. Sejnowski
Regulation of Persistent Activity by Background Inhibition in an In Vitro Model of a Cortical Microcircuit
Cereb Cortex, November 1, 2003; 13(11): 1232 - 1241.
[Abstract] [Full Text] [PDF]

Home page
 Neural Comput.Home page
E. Salinas
Background Synaptic Activity as a Switch Between Dynamical States in a Network
Neural Comput., July 1, 2003; 15(7): 1439 - 1475.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
B. Doiron, L. Noonan, N. Lemon, and R. W. Turner
Persistent Na+ Current Modifies Burst Discharge By Regulating Conditional Backpropagation of Dendritic Spikes
J Neurophysiol, January 1, 2003; 89(1): 324 - 337.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. C. W. van Rossum, G. G. Turrigiano, and S. B. Nelson
Fast Propagation of Firing Rates through Layered Networks of Noisy Neurons
J. Neurosci., March 1, 2002; 22(5): 1956 - 1966.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. R. Williams and G. J. Stuart
Backpropagation of Physiological Spike Trains in Neocortical Pyramidal Neurons: Implications for Temporal Coding in Dendrites
J. Neurosci., November 15, 2000; 20(22): 8238 - 8246.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
E. Salinas and T. J. Sejnowski
Impact of Correlated Synaptic Input on Output Firing Rate and Variability in Simple Neuronal Models
J. Neurosci., August 15, 2000; 20(16): 6193 - 6209.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
B. J. Hefti and P. H. Smith
Anatomy, Physiology, and Synaptic Responses of Rat Layer V Auditory Cortical Cells and Effects of Intracellular GABAA Blockade
J Neurophysiol, May 1, 2000; 83(5): 2626 - 2638.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
V. Gauck and D. Jaeger
The Control of Rate and Timing of Spikes in the Deep Cerebellar Nuclei by Inhibition
J. Neurosci., April 15, 2000; 20(8): 3006 - 3016.
[Abstract] [Full Text] [PDF]

Home page
 Neural Comput.Home page
M. A. Kisley and G. L. Gerstein
The Continuum of Operating Modes for a Passive Model Neuron
Neural Comput., July 1, 1999; 11(5): 1139 - 1154.
[Abstract] [Full Text]

Home page
 J. Neurosci.Home page
P. Kara and M. J. Friedlander
Arginine Analogs Modify Signal Detection by Neurons in the Visual Cortex
J. Neurosci., July 1, 1999; 19(13): 5528 - 5548.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
R. Azouz and C. M. Gray
Cellular Mechanisms Contributing to Response Variability of Cortical Neurons In Vivo
J. Neurosci., March 15, 1999; 19(6): 2209 - 2223.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. D. Hunter, J. G. Milton, P. J. Thomas, and J. D. Cowan
Resonance Effect for Neural Spike Time Reliability
J Neurophysiol, September 1, 1998; 80(3): 1427 - 1438.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. D. Victor and K. P. Purpura
Spatial Phase and the Temporal Structure of the Response to Gratings in V1
J Neurophysiol, August 1, 1998; 80(2): 554 - 571.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
P. Faure and H. Korn
A nonrandom dynamic component in the synaptic noise of a central neuron
PNAS, June 10, 1997; 94(12): 6506 - 6511.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
E. A. Stern, A. E. Kincaid, and C. J. Wilson
Spontaneous Subthreshold Membrane Potential Fluctuations and Action Potential Variability of Rat Corticostriatal and Striatal Neurons In Vivo
J Neurophysiol, April 1, 1997; 77(4): 1697 - 1715.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online