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Journal of Neurophysiology, Vol 70, Issue 4 1704-1707, Copyright © 1993 by APS
ARTICLES |
X. M. Yu, B. J. Sessle and J. W. Hu
Faculty of Dentistry, University of Toronto, Ontario, Canada.
1. The aim of this study was to determine whether there are differential neuroplastic effects of cutaneous and deep stimuli on the mechanoreceptive field (RF) properties of nociceptive brain stem neurons recorded in trigeminal (V) subnucleus caudalis. 2. A total of 31 caudalis neurons were functionally identified in anesthetized rats as nociceptive neurons receiving convergent cutaneous and deep afferent inputs, and the effects of the small-fiber excitant and inflammatory irritant mustard oil applied to either tongue muscle or facial skin were tested on their cutaneous and deep RFs. 3. The expression of neuroplasticity on the cutaneous and deep RFs of the neurons was found to depend on the site of application of this irritant. Mustard oil injected into the tongue muscle produced a significant and reversible expansion of both the cutaneous and deep RFs. In contrast, application of mustard oil to facial skin resulted in a significant and reversible expansion of the cutaneous RF, but no deep RF expansion occurred. 4. These findings suggest that considerable functional neuroplasticity of the cutaneous and deep RF properties of V nociceptive neurons can be induced by a peripheral inflammatory irritant and that deep inputs are especially effective in evoking these neuroplastic changes.
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C. Y. Chiang, B. Hu, J. W. Hu, J. O. Dostrovsky, and B. J. Sessle Central Sensitization of Nociceptive Neurons in Trigeminal Subnucleus Oralis Depends on Integrity of Subnucleus Caudalis J Neurophysiol, July 1, 2002; 88(1): 256 - 264. [Abstract] [Full Text] [PDF]
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T. Bartsch and P. J. Goadsby Stimulation of the greater occipital nerve induces increased central excitability of dural afferent input Brain, July 1, 2002; 125(7): 1496 - 1509. [Abstract] [Full Text] [PDF]
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B. E. Cairns, B. J. Sessle, and J. W. Hu Characteristics of Glutamate-Evoked Temporomandibular Joint Afferent Activity in the Rat J Neurophysiol, June 1, 2001; 85(6): 2446 - 2454. [Abstract] [Full Text] [PDF]
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S. J. Park, C. Y. Chiang, J. W. Hu, and B. J. Sessle Neuroplasticity Induced by Tooth Pulp Stimulation in Trigeminal Subnucleus Oralis Involves NMDA Receptor Mechanisms J Neurophysiol, May 1, 2001; 85(5): 1836 - 1846. [Abstract] [Full Text] [PDF]
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J.-M. Dessirier, C. T. Simons, M. Sudo, S. Sudo, and E. Carstens Sensitization, Desensitization and Stimulus-Induced Recovery of Trigeminal Neuronal Responses to Oral Capsaicin and Nicotine J Neurophysiol, October 1, 2000; 84(4): 1851 - 1862. [Abstract] [Full Text] [PDF]
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C. Y. Chiang, C. L. Kwan, J. W. Hu, and B. J. Sessle Effects of GABA Receptor Antagonist on Trigeminal Caudalis Nociceptive Neurons in Normal and Neonatally Capsaicin-Treated Rats J Neurophysiol, November 1, 1999; 82(5): 2154 - 2162. [Abstract] [Full Text] [PDF]
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K. Iwata, A. Tashiro, Y. Tsuboi, T. Imai, R. Sumino, T. Morimoto, R. Dubner, and K. Ren Medullary Dorsal Horn Neuronal Activity in Rats with Persistent Temporomandibular Joint and Perioral Inflammation J Neurophysiol, September 1, 1999; 82(3): 1244 - 1253. [Abstract] [Full Text] [PDF]
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D. B. Katz, S. A. Simon, A. Moody, and M. A. L. Nicolelis Simultaneous Reorganization in Thalamocortical Ensembles Evolves Over Several Hours After Perioral Capsaicin Injections J Neurophysiol, August 1, 1999; 82(2): 963 - 977. [Abstract] [Full Text] [PDF]
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C. Y. Chiang, S. J. Park, C. L. Kwan, J. W. Hu, and B. J. Sessle NMDA Receptor Mechanisms Contribute to Neuroplasticity Induced in Caudalis Nociceptive Neurons by Tooth Pulp Stimulation J Neurophysiol, November 1, 1998; 80(5): 2621 - 2631. [Abstract] [Full Text] [PDF]
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E. Carstens, N. Kuenzler, and H. O. Handwerker Activation of Neurons in Rat Trigeminal Subnucleus Caudalis by Different Irritant Chemicals Applied to Oral or Ocular Mucosa J Neurophysiol, August 1, 1998; 80(2): 465 - 492. [Abstract] [Full Text] [PDF]
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C. Y. Chiang, J. W. Hu, and B. J. Sessle NMDA Receptor Involvement in Neuroplastic Changes Induced By Neonatal Capsaicin Treatment in Trigeminal Nociceptive Neurons J Neurophysiol, November 1, 1997; 78(5): 2799 - 2803. [Abstract] [Full Text] [PDF]
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