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J Neurophysiol 68: 1642-1653, 1992;
0022-3077/92 $5.00
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Journal of Neurophysiology, Vol 68, Issue 5 1642-1653, Copyright © 1992 by APS

ARTICLES

The inactivating potassium currents of hair cells isolated from the crista ampullaris of the frog

C. H. Norris, A. J. Ricci, G. D. Housley and P. S. Guth
Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana 70112.

1. A-type outward currents were studied in sensory hair cells isolated from the semicircular canals (SCC) of the leopard frog (Rana pipiens) with whole-cell voltage- and current-clamping techniques. 2. There appear to be two classes of A-type outward-conducting potassium channels based on steady-state, kinetic, pharmacological parameters, and reversal potential. 3. The two classes of A-type currents differ in their steady-state inactivation properties as well as in the kinetics of inactivation. The steady-state inactivation properties are such that a significant portion of the fast channels are available from near the resting potential. 4. The inactivating channels studied do not appear to be calcium dependent. 5. The A-channels in hair cells appear to subserve functions that are analogous to IA functions in neurons, that is, modulating spike latency and Q (the oscillatory damping function). The A-currents appear to temporally limit the hair cell voltage response to a current injection.


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