JN Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 66: 729-734, 1991;
0022-3077/91 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by White, D. M.
Right arrow Articles by Levine, J. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by White, D. M.
Right arrow Articles by Levine, J. D.

Journal of Neurophysiology, Vol 66, Issue 3 729-734, Copyright © 1991 by APS

ARTICLES

Delayed activation of nociceptors: correlation with delayed pain sensations induced by sustained stimuli

D. M. White, Y. O. Taiwo, T. J. Coderre and J. D. Levine
Department of Medicine, University of California, San Francisco 94143.

1. In this study we used psychophysical experiments in humans and behavioral and electrophysiological studies in rats to evaluate nociceptive and C-fiber mechanoheat nociceptor (C-MH) responses to sustained mechanical stimuli that are initially nonpainful or nonnoxious. 2. In normal rat skin, sustained subthreshold mechanical stimuli activate C-MHs (n = 36) with a delayed onset that parallels the delayed pain sensation recorded in human psychophysical tests. 3. The subthreshold stimuli did not induce a decrease in mechanical threshold (n = 11), and the effect of the subthreshold stimulus on latency to firing of C-MHs (n = 6) persists for a very short time after the stimulus is removed (less than 10 s). 4. Intradermal injection of prostaglandin E2 (PGE2; 100 ng), which induced a significant decrease in the mechanical threshold of C-MHs (n = 7), had no effect on the latency of the delayed activation of C-MHs. Also, indomethacin, which inhibits the synthesis of prostaglandins, had no effect on the latency of the delayed paw-withdrawal response in the behavioral test. 5. Intradermal injection of the calcium ionophore A23187 significantly reduced the latency of the delayed activation of C-MHs (n = 6) the calcium chelator Quin 2 (n = 6) significantly increased the latency. A23187 and Quin 2 had similar effects on the latencies to paw withdrawal in behavioral tests. The sensitization of C-MHs (n = 9) by PGE2 was not, however, affected by Quin 2.(ABSTRACT TRUNCATED AT 250 WORDS)


This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
D. Andrew and J. D. Greenspan
Peripheral Coding of Tonic Mechanical Cutaneous Pain: Comparison of Nociceptor Activity in Rat and Human Psychophysics
J Neurophysiol, November 1, 1999; 82(5): 2641 - 2648.
[Abstract] [Full Text] [PDF]

Home page
 CROBMHome page
M.R. Byers and M.V.O. Narhi
Dental Injury Models: Experimental Tools for Understanding Neuroinflammatory Interactions and Polymodal Nociceptor Functions
Critical Reviews in Oral Biology & Medicine, January 1, 1999; 10(1): 4 - 39.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
P. S. Khalsa, R. H. Lamotte, and P. Grigg
Tensile and Compressive Responses of Nociceptors in Rat Hairy Skin
J Neurophysiol, July 1, 1997; 78(1): 492 - 505.
[Abstract] [Full Text] [PDF]

Home page
 CROBMHome page
C. L. Haskin, S. B. Milam, and I. L. Cameron
Pathogenesis of Degenerative Joint Disease in the Human Temporomandibular Joint
Critical Reviews in Oral Biology & Medicine, January 1, 1995; 6(3): 248 - 277.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online