JN AJP: Gastrointestinal and Liver Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 66: 228-246, 1991;
0022-3077/91 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Simone, D. A.
Right arrow Articles by Willis, W. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Simone, D. A.
Right arrow Articles by Willis, W. D.

Journal of Neurophysiology, Vol 66, Issue 1 228-246, Copyright © 1991 by APS

ARTICLES

Neurogenic hyperalgesia: central neural correlates in responses of spinothalamic tract neurons

D. A. Simone, L. S. Sorkin, U. Oh, J. M. Chung, C. Owens, R. H. LaMotte and W. D. Willis
Department of Anesthesiology, Yale University School of Medicine, New Haven, Connecticut 06510.

1. The contribution of activity in spinothalamic tract (STT) neurons to the pain and neurogenic hyperalgesia produced by an intradermal injection of 100 micrograms of capsaicin was investigated. Electrophysiological responses of identified STT neurons recorded in anesthetized monkeys were compared with psychophysical measurements of pain and hyperalgesia obtained in humans using identical stimuli. 2. Magnitude estimates of pain in humans were obtained after an injection of capsaicin or the vehicle. Capsaicin produced immediate burning pain that was most intense within 15 s after injection and then declined over the next 10-30 min. The vehicle produced no pain. 3. Cutaneous hyperalgesia to gentle stroking (allodynia) and also hyperalgesia to punctate stimulation developed in a wide area surrounding the capsaicin injection. Within this area, magnitude estimates of pain produced by a punctate stimulus (von Frey type with force of 225 mN) increased over preinjection values by an average of sixfold at test sites, 1, 2, and 3 cm away from the injection site. At the capsaicin injection site, magnitude estimates of pain in response to punctate simulation typically remained the same or were decreased. 4. After capsaicin, but not vehicle, the mean heat pain thresholds were lowered from approximately 45 degrees C before injection to 34 degrees C after, but only in the immediate vicinity of the injection site. At a site located 2 cm away, the thresholds were not significantly altered. Similarly, magnitude estimates of pain produced by suprathreshold heat stimuli were increased after capsaicin only at the injection site. 5. STT neurons were classified as high-threshold (HT) or wide-dynamic-range (WDR) cells according to responses evoked by graded cutaneous mechanical stimulation. An intradermal injection of capsaicin excited 4 of 7 HT cells and 10 of 12 WDR cells. The discharge rates of STT neurons correlated in time course with the magnitude estimates of pain in humans. The correlation was considerably better for WDR than for HT neurons, suggesting a predominant contribution of WDR neurons to the pain from capsaicin. 6. Capsaicin significantly increased the responses of HT neurons (9-fold) and the responses of WDR neurons (2-fold) to stroking the skin within the receptive field. Similar increases in responses to a standard punctate stimulus were observed at test sites, 1, 2, and 3 cm away from the injection site. After injection of vehicle, the responses to punctate stimulation increased by a mean of only 1.2- and 1.4-fold for HT and WDR neurons, respectively.(ABSTRACT TRUNCATED AT 400 WORDS)


This article has been cited by other articles:


Home page
 J. Neurosci.Home page
S. Neumann, J. M. Braz, K. Skinner, I. J. Llewellyn-Smith, and A. I. Basbaum
Innocuous, Not Noxious, Input Activates PKC{gamma} Interneurons of the Spinal Dorsal Horn via Myelinated Afferent Fibers
J. Neurosci., August 6, 2008; 28(32): 7936 - 7944.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. Kohno, H. Wang, F. Amaya, G. J. Brenner, J.-K. Cheng, R.-R. Ji, and C. J. Woolf
Bradykinin Enhances AMPA and NMDA Receptor Activity in Spinal Cord Dorsal Horn Neurons by Activating Multiple Kinases to Produce Pain Hypersensitivity
J. Neurosci., April 23, 2008; 28(17): 4533 - 4540.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
E. Garcia-Nicas, J. M. A. Laird, and F. Cervero
GABAA-Receptor Blockade Reverses the Injury-Induced Sensitization of Nociceptor-Specific (NS) Neurons in the Spinal Dorsal Horn of the Rat
J Neurophysiol, August 1, 2006; 96(2): 661 - 670.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
H. Ikeda, J. Stark, H. Fischer, M. Wagner, R. Drdla, T. Jager, and J. Sandkuhler
Synaptic amplifier of inflammatory pain in the spinal dorsal horn.
Science, June 16, 2006; 312(5780): 1659 - 1662.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Y. Guan, J. Borzan, R. A. Meyer, and S. N. Raja
Windup in dorsal horn neurons is modulated by endogenous spinal mu-opioid mechanisms.
J. Neurosci., April 19, 2006; 26(16): 4298 - 4307.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
C. Maihofner, H. O. Handwerker, and F. Birklein
Functional imaging of allodynia in complex regional pain syndrome
Neurology, March 14, 2006; 66(5): 711 - 717.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
H. Wang, T. Kohno, F. Amaya, G. J. Brenner, N. Ito, A. Allchorne, R.-R. Ji, and C. J. Woolf
Bradykinin Produces Pain Hypersensitivity by Potentiating Spinal Cord Glutamatergic Synaptic Transmission
J. Neurosci., August 31, 2005; 25(35): 7986 - 7992.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
N. Nozaki-Taguchi and T. Yamamoto
Spinal Opioid Receptor Like1 Receptor Agonist, but Not N-Methyl-D-Aspartic Acid Antagonist, Reverses the Secondary Mechanical Allodynia Induced by Intradermal Injection of Capsaicin in Rats
Anesth. Analg., April 1, 2005; 100(4): 1087 - 1092.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
L. M. Johanek and D. A. Simone
Cannabinoid Agonist, CP 55,940, Prevents Capsaicin-Induced Sensitization of Spinal Cord Dorsal Horn Neurons
J Neurophysiol, February 1, 2005; 93(2): 989 - 997.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
C. K. Jones, S. C. Peters, and H. E. Shannon
Efficacy of Duloxetine, a Potent and Balanced Serotonergic and Noradrenergic Reuptake Inhibitor, in Inflammatory and Acute Pain Models in Rodents
J. Pharmacol. Exp. Ther., February 1, 2005; 312(2): 726 - 732.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. G. Nackley, A. M. Zvonok, A. Makriyannis, and A. G. Hohmann
Activation of Cannabinoid CB2 Receptors Suppresses C-Fiber Responses and Windup in Spinal Wide Dynamic Range Neurons in the Absence and Presence of Inflammation
J Neurophysiol, December 1, 2004; 92(6): 3562 - 3574.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
R.-Q. Sun, N. B. Lawand, Q. Lin, and W. D. Willis
Role of Calcitonin Gene-Related Peptide in the Sensitization of Dorsal Horn Neurons to Mechanical Stimulation After Intradermal Injection of Capsaicin
J Neurophysiol, July 1, 2004; 92(1): 320 - 326.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
G. G. Nagy, M. Al-Ayyan, D. Andrew, M. Fukaya, M. Watanabe, and A. J. Todd
Widespread Expression of the AMPA Receptor GluR2 Subunit at Glutamatergic Synapses in the Rat Spinal Cord and Phosphorylation of GluR1 in Response to Noxious Stimulation Revealed with an Antigen-Unmasking Method
J. Neurosci., June 23, 2004; 24(25): 5766 - 5777.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. Serra, M. Campero, H. Bostock, and J. Ochoa
Two Types of C Nociceptors in Human Skin and Their Behavior in Areas of Capsaicin-Induced Secondary Hyperalgesia
J Neurophysiol, June 1, 2004; 91(6): 2770 - 2781.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
K. Stiasny-Kolster, W. Magerl, W. H. Oertel, J. C. Moller, and R.-D. Treede
Static mechanical hyperalgesia without dynamic tactile allodynia in patients with restless legs syndrome
Brain, April 1, 2004; 127(4): 773 - 782.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. Klein, W. Magerl, H.-C. Hopf, J. Sandkuhler, and R.-D. Treede
Perceptual Correlates of Nociceptive Long-Term Potentiation and Long-Term Depression in Humans
J. Neurosci., January 28, 2004; 24(4): 964 - 971.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
D. A. Simone, X. Zhang, J. Li, J.-M. Zhang, C. N. Honda, R. H. LaMotte, and G. J. Giesler Jr.
Comparison of Responses of Primate Spinothalamic Tract Neurons to Pruritic and Algogenic Stimuli
J Neurophysiol, January 1, 2004; 91(1): 213 - 222.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
Y. B. Peng, Q. D. Ling, M. A. Ruda, and D. R. Kenshalo
Electrophysiological Changes in Adult Rat Dorsal Horn Neurons After Neonatal Peripheral Inflammation
J Neurophysiol, July 1, 2003; 90(1): 73 - 80.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
J. D. Pomonis, J. E. Harrison, L. Mark, D. R. Bristol, K. J. Valenzano, and K. Walker
N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a Novel, Orally Effective Vanilloid Receptor 1 Antagonist with Analgesic Properties: II. In Vivo Characterization in Rat Models of Inflammatory and Neuropathic Pain
J. Pharmacol. Exp. Ther., July 1, 2003; 306(1): 387 - 393.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
K. M. Walker, L. Urban, S. J. Medhurst, S. Patel, M. Panesar, A. J. Fox, and P. McIntyre
The VR1 Antagonist Capsazepine Reverses Mechanical Hyperalgesia in Models of Inflammatory and Neuropathic Pain
J. Pharmacol. Exp. Ther., January 1, 2003; 304(1): 56 - 62.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. G. Khasabov, S. D. Rogers, J. R. Ghilardi, C. M. Peters, P. W. Mantyh, and D. A. Simone
Spinal Neurons that Possess the Substance P Receptor Are Required for the Development of Central Sensitization
J. Neurosci., October 15, 2002; 22(20): 9086 - 9098.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
K. A. Sluka
Stimulation of Deep Somatic Tissue with Capsaicin Produces Long-Lasting Mechanical Allodynia and Heat Hypoalgesia that Depends on Early Activation of the cAMP Pathway
J. Neurosci., July 1, 2002; 22(13): 5687 - 5693.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
L. Fang, J. Wu, Q. Lin, and W. D. Willis
Calcium-Calmodulin-Dependent Protein Kinase II Contributes to Spinal Cord Central Sensitization
J. Neurosci., May 15, 2002; 22(10): 4196 - 4204.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. M. Hamalainen, G. F. Gebhart, and T. J. Brennan
Acute Effect of an Incision on Mechanosensitive Afferents in the Plantar Rat Hindpaw
J Neurophysiol, February 1, 2002; 87(2): 712 - 720.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
L. Zhang, Y. Lu, Y. Chen, and K. N. Westlund
Group I Metabotropic Glutamate Receptor Antagonists Block Secondary Thermal Hyperalgesia in Rats with Knee Joint Inflammation
J. Pharmacol. Exp. Ther., January 1, 2002; 300(1): 149 - 156.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
N. Witting, R. C. Kupers, P. Svensson, L. Arendt-Nielsen; A. Gjedde, and T. S. Jensen
Experimental brush-evoked allodynia activates posterior parietal cortex
Neurology, November 27, 2001; 57(10): 1817 - 1824.
[Abstract] [Full Text] [PDF]

Home page
 Canadian J. AnesthesiaHome page
D. J. Kelly, M. Ahmad, and S. J. Brull
Preemptive analgesia I: physiological pathways and pharmacological modalities : [L'analgesie preventive I : mecanismes physiologiques et modalites pharmacologiques]
Can J Anesth, November 1, 2001; 48(10): 1000 - 1010.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
W. Magerl, P. N. Fuchs, R. A. Meyer, and R.-D. Treede
Roles of capsaicin-insensitive nociceptors in cutaneous pain and secondary hyperalgesia
Brain, September 1, 2001; 124(9): 1754 - 1764.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. Tinazzi, A. Fiaschi, T. Rosso, F. Faccioli, J. Grosslercher, and S. M. Aglioti
Neuroplastic Changes Related to Pain Occur at Multiple Levels of the Human Somatosensory System: A Somatosensory-Evoked Potentials Study in Patients with Cervical Radicular Pain
J. Neurosci., December 15, 2000; 20(24): 9277 - 9283.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
V. Neugebauer, P.-S. Chen, and W. D. Willis
Groups II and III Metabotropic Glutamate Receptors Differentially Modulate Brief and Prolonged Nociception in Primate STT Cells
J Neurophysiol, December 1, 2000; 84(6): 2998 - 3009.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J.-M. Dessirier, C. T. Simons, M. Sudo, S. Sudo, and E. Carstens
Sensitization, Desensitization and Stimulus-Induced Recovery of Trigeminal Neuronal Responses to Oral Capsaicin and Nicotine
J Neurophysiol, October 1, 2000; 84(4): 1851 - 1862.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
H. Gottrup, F. W. Bach, L. Arendt-Nielsen, and T. S. Jensen
Peripheral lidocaine but not ketamine inhibits capsaicin-induced hyperalgesia in humans
Br. J. Anaesth., October 1, 2000; 85(4): 520 - 528.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
X. Zou, Q. Lin, and W. D. Willis
Enhanced Phosphorylation of NMDA Receptor 1 Subunits in Spinal Cord Dorsal Horn and Spinothalamic Tract Neurons after Intradermal Injection of Capsaicin in Rats
J. Neurosci., September 15, 2000; 20(18): 6989 - 6997.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
R. Burstein, M. F. Cutrer, and D. Yarnitsky
The development of cutaneous allodynia during a migraine attack Clinical evidence for the sequential recruitment of spinal and supraspinal nociceptive neurons in migraine
Brain, August 1, 2000; 123(8): 1703 - 1709.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
C. J. Woolf and M. W. Salter
Neuronal Plasticity: Increasing the Gain in Pain
Science, June 9, 2000; 288(5472): 1765 - 1768.
[Abstract] [Full Text] [PDF]

Home page
 Canadian J. AnesthesiaHome page
T. Yamamoto, Y. Sakashita, and N. Nozaki-Taguchi
Anti-allodynic effects of oral COX-2 selective inhibitor on postoperative pain in the rat
Can J Anesth, April 1, 2000; 47(4): 354 - 360.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
S. L. Jinks and E. Carstens
Activation of Spinal Wide Dynamic Range Neurons by Intracutaneous Microinjection of Nicotine
J Neurophysiol, December 1, 1999; 82(6): 3046 - 3055.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
X.-J. Song, S.-J. Hu, K. W. Greenquist, J.-M. Zhang, and R. H. LaMotte
Mechanical and Thermal Hyperalgesia and Ectopic Neuronal Discharge After Chronic Compression of Dorsal Root Ganglia
J Neurophysiol, December 1, 1999; 82(6): 3347 - 3358.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
E. A. Ziegler, W. Magerl, R. A. Meyer, and R.-D. Treede
Secondary hyperalgesia to punctate mechanical stimuli: Central sensitization to A-fibre nociceptor input
Brain, December 1, 1999; 122(12): 2245 - 2257.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
M. L. Nichols, B. J. Allen, S. D. Rogers, J. R. Ghilardi, P. Honore, N. M. Luger, M. P. Finke, J. Li, D. A. Lappi, D. A. Simone, et al.
Transmission of Chronic Nociception by Spinal Neurons Expressing the Substance P Receptor
Science, November 19, 1999; 286(5444): 1558 - 1561.
[Abstract] [Full Text]

Home page
 J. Neurosci.Home page
P. Honore, P. M. Menning, S. D. Rogers, M. L. Nichols, A. I. Basbaum, J.-M. Besson, and P. W. Mantyh
Spinal Substance P Receptor Expression and Internalization in Acute, Short-Term, and Long-Term Inflammatory Pain States
J. Neurosci., September 1, 1999; 19(17): 7670 - 7678.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
D. B. Katz, S. A. Simon, A. Moody, and M. A. L. Nicolelis
Simultaneous Reorganization in Thalamocortical Ensembles Evolves Over Several Hours After Perioral Capsaicin Injections
J Neurophysiol, August 1, 1999; 82(2): 963 - 977.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. L. Yaksh, X.-Y. Hua, I. Kalcheva, N. Nozaki-Taguchi, and M. Marsala
The spinal biology in humans and animals of pain states generated by persistent small afferent input
PNAS, July 6, 1999; 96(14): 7680 - 7686.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
V. Neugebauer, P.-S. Chen, and W. D. Willis
Role of Metabotropic Glutamate Receptor Subtype mGluR1 in Brief Nociception and Central Sensitization of Primate STT Cells
J Neurophysiol, July 1, 1999; 82(1): 272 - 282.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
A. Szallasi and P. M. Blumberg
Vanilloid (Capsaicin) Receptors and Mechanisms
Pharmacol. Rev., June 1, 1999; 51(2): 159 - 212.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
Q. Lin, J. Palecek, V. Paleckova, Y. B. Peng, J. Wu, M. Cui, and W. D. Willis
Nitric Oxide Mediates the Central Sensitization of Primate Spinothalamic Tract Neurons
J Neurophysiol, March 1, 1999; 81(3): 1075 - 1085.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
K.-F. Sjolund, M. Segerdahl, and A. Sollevi
Adenosine Reduces Secondary Hyperalgesia in Two Human Models of Cutaneous Inflammatory Pain
Anesth. Analg., March 1, 1999; 88(3): 605 - 605.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. Serra, M. Campero, and J. Ochoa
Flare and Hyperalgesia After Intradermal Capsaicin Injection in Human Skin
J Neurophysiol, December 1, 1998; 80(6): 2801 - 2810.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
G. Lauria, J. C McArthur, P. E Hauer, J. W Griffin, and D. R Cornblath
Neuropathological alterations in diabetic truncal neuropathy: evaluation by skin biopsy
J. Neurol. Neurosurg. Psychiatry, November 1, 1998; 65(5): 762 - 766.
[Abstract] [Full Text]

Home page
 J. Neurophysiol.Home page
R. Burstein, H. Yamamura, A. Malick, and A. M. Strassman
Chemical Stimulation of the Intracranial Dura Induces Enhanced Responses to Facial Stimulation in Brain Stem Trigeminal Neurons
J Neurophysiol, February 1, 1998; 79(2): 964 - 982.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
P. W. Mantyh, S. D. Rogers, P. Honore, B. J. Allen, J. R. Ghilardi, J. Li, R. S. Daughters, D. A. Lappi, R. G. Wiley, and D. A. Simone
Inhibition of Hyperalgesia by Ablation of Lamina I Spinal Neurons Expressing the Substance P Receptor
Science, October 10, 1997; 278(5336): 275 - 279.
[Abstract] [Full Text]

Home page
 J. Neurophysiol.Home page
E. Carstens
Responses of Rat Spinal Dorsal Horn Neurons to Intracutaneous Microinjection of Histamine, Capsaicin, and Other Irritants
J Neurophysiol, May 1, 1997; 77(5): 2499 - 2514.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Q. Lin, Y. B. Peng, J. Wu, and W. D. Willis
Involvement of cGMP in Nociceptive Processing by and Sensitization of Spinothalamic Neurons in Primates
J. Neurosci., May 1, 1997; 17(9): 3293 - 3302.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Q. Lin, Y. B. Peng, and W. D. Willis
Possible Role of Protein Kinase C in the Sensitization of Primate Spinothalamic Tract Neurons
J. Neurosci., May 1, 1996; 16(9): 3026 - 3034.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
P. Mantyh, E DeMaster, A Malhotra, Ghilardi JR, S. Rogers, C. Mantyh, H Liu, A. Basbaum, Vigna SR, J. Maggio, et al.
Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation
Science, June 16, 1995; 268(5217): 1629 - 1632.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online