| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Neurophysiology, Vol 63, Issue 6 1385-1400, Copyright © 1990 by APS
ARTICLES |
T. Sawaguchi, M. Matsumura and K. Kubota
Department of Neurophysiology, Kyoto University, Aichi, Japan.
1. Using iontophoretic techniques, we investigated the effects of dopamine (DA) and noradrenaline (NA) on neuronal activity related to a delayed response (DR) task in the prefrontal cortex (PFC) of the Japanese macaque monkeys. The DR task was initiated by rotation of a handle to a central zone and consisted of seven distinct time periods: an initial waiting period of 0.3 s, a precue period of 1 s (a central green lamp), a cue period of 1 s (left or right lamp), a delay period of 4 s, a go period of 1 s (red lamp in the center; rotation of the handle to either the left or right zone), a hold period (holding of the handle in either the left or right zone for 0.3 s), and a final reward period. 2. A total of 116 neurons were DR task related. They showed increases in activity during the precue period (Precue-types, n = 19), during both the cue and go periods (Cue/GO-types, n = 17), the go period (GO-types, n = 16), and during the delay period (Delay-types, n = 64). The Delay-type neurons were further divided into differential neurons (n = 33), for which the magnitude of the delay-related activity differed significantly between left- and right-cue trials, and nondifferential neurons (n = 31). Some of the Delay-type neurons also showed increases in activity during the cue (n = 26), go (n = 27), or both the cue and go periods (n = 11). 3. DA or NA, applied iontophoretically with a current of 50 nA, induced increased or decreased responses in most of the DR task-related neurons. DA increased activity of most of the Cue/GO-(16/17), GO-(13/16), and Delay-type neurons (49/64), and NA decreased activity of most of the Precue- (13/19) and non-differential Delay-type neurons (25/31). Thus different types of DR task-related neurons showed different responses to DA and NA. 4. In Cue/GO-, GO-, and/or Delay-type neurons, DA increased the activity related to the cue, go, and delay periods more strongly than it increased background activity. As a result, the ratio [i.e., signal-to-noise (S/N) ratio] of activity related to the cue, go, and delay periods to background activity was increased. 5. In Precue-type or nondifferential Delay-type neurons, NA decreased background activity more strongly than it decreased activity during the precue or delay period.(ABSTRACT TRUNCATED AT 400 WORDS)
This article has been cited by other articles:
|
|
 |
|
  M.-F. Kuo, W. Paulus, and M. A. Nitsche Boosting Focally-Induced Brain Plasticity by Dopamine Cereb Cortex, March 1, 2008; 18(3): 648 - 651. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. B. Carr, G. D. Andrews, W. B. Glen, and A. Lavin {alpha}2-Noradrenergic receptors activation enhances excitability and synaptic integration in rat prefrontal cortex pyramidal neurons via inhibition of HCN currents J. Physiol., October 15, 2007; 584(2): 437 - 450. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Rosenkranz and D. Johnston State-Dependent Modulation of Amygdala Inputs by Dopamine-Induced Enhancement of Sodium Currents in Layer V Entorhinal Cortex J. Neurosci., June 27, 2007; 27(26): 7054 - 7069. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Kuboshima-Amemori and T. Sawaguchi Plasticity of the Primate Prefrontal Cortex Neuroscientist, June 1, 2007; 13(3): 229 - 240. [Abstract] [PDF]
|
|
|
|
 |
|
 S. Bandyopadhyay and J. J. Hablitz Dopaminergic Modulation of Local Network Activity in Rat Prefrontal Cortex J Neurophysiol, June 1, 2007; 97(6): 4120 - 4128. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. L. Rossetti and S. Carboni Noradrenaline and Dopamine Elevations in the Rat Prefrontal Cortex in Spatial Working Memory J. Neurosci., March 2, 2005; 25(9): 2322 - 2329. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Owen Cognitive Dysfunction in Parkinson's Disease: The Role of Frontostriatal Circuitry Neuroscientist, December 1, 2004; 10(6): 525 - 537. [Abstract] [PDF]
|
|
|
|
|
|
H. Trantham-Davidson, L. C. Neely, A. Lavin, and J. K. Seamans Mechanisms Underlying Differential D1 versus D2 Dopamine Receptor Regulation of Inhibition in Prefrontal Cortex J. Neurosci., November 24, 2004; 24(47): 10652 - 10659. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. K. S. Voeller Attention-Deficit Hyperactivity Disorder (ADHD) J Child Neurol, October 1, 2004; 19(10): 798 - 814. [Abstract] [PDF]
|
|
|
|
|
|
I. A. Yun, K. T. Wakabayashi, H. L. Fields, and S. M. Nicola The Ventral Tegmental Area Is Required for the Behavioral and Nucleus Accumbens Neuronal Firing Responses to Incentive Cues J. Neurosci., March 24, 2004; 24(12): 2923 - 2933. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. K. Seamans, L. Nogueira, and A. Lavin Synaptic Basis of Persistent Activity in Prefrontal Cortex In Vivo and in Organotypic Cultures Cereb Cortex, November 1, 2003; 13(11): 1242 - 1250. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Escola, Th. Michelet, F. Macia, D. Guehl, B. Bioulac, and P. Burbaud Disruption of information processing in the supplementary motor area of the MPTP-treated monkey: A clue to the pathophysiology of akinesia? Brain, January 1, 2003; 126(1): 95 - 114. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Cools, E. Stefanova, R. A. Barker, T. W. Robbins, and A. M. Owen Dopaminergic modulation of high-level cognition in Parkinson's disease: the role of the prefrontal cortex revealed by PET Brain, March 1, 2002; 125(3): 584 - 594. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. K. Seamans, N. Gorelova, D. Durstewitz, and C. R. Yang Bidirectional Dopamine Modulation of GABAergic Inhibition in Prefrontal Cortical Pyramidal Neurons J. Neurosci., May 15, 2001; 21(10): 3628 - 3638. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Henze, G. R. Gonzalez-Burgos, N. N. Urban, D. A. Lewis, and G. Barrionuevo Dopamine Increases Excitability of Pyramidal Neurons in Primate Prefrontal Cortex J Neurophysiol, December 1, 2000; 84(6): 2799 - 2809. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. K. Lambe, L. S. Krimer, and P. S. Goldman-Rakic Differential Postnatal Development of Catecholamine and Serotonin Inputs to Identified Neurons in Prefrontal Cortex of Rhesus Monkey J. Neurosci., December 1, 2000; 20(23): 8780 - 8787. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Compte, N. Brunel, P. S. Goldman-Rakic, and X.-J. Wang Synaptic Mechanisms and Network Dynamics Underlying Spatial Working Memory in a Cortical Network Model Cereb Cortex, September 1, 2000; 10(9): 910 - 923. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Durstewitz, J. K. Seamans, and T. J. Sejnowski Dopamine-Mediated Stabilization of Delay-Period Activity in a Network Model of Prefrontal Cortex J Neurophysiol, March 1, 2000; 83(3): 1733 - 1750. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Sawaguchi and I. Yamane Properties of Delay-Period Neuronal Activity in the Monkey Dorsolateral Prefrontal Cortex During a Spatial Delayed Matching-to-Sample Task J Neurophysiol, November 1, 1999; 82(5): 2070 - 2080. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Durstewitz, M. Kelc, and O. Gunturkun A Neurocomputational Theory of the Dopaminergic Modulation of Working Memory Functions J. Neurosci., April 1, 1999; 19(7): 2807 - 2822. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. R. Richardson and A. Gratton Changes in Medial Prefrontal Cortical Dopamine Levels Associated with Response-Contingent Food Reward: An Electrochemical Study in Rat J. Neurosci., November 1, 1998; 18(21): 9130 - 9138. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Sawaguchi Attenuation of Delay-Period Activity of Monkey Prefrontal Neurons by an alpha 2-Adrenergic Antagonist During an Oculomotor Delayed-Response Task J Neurophysiol, October 1, 1998; 80(4): 2200 - 2205. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. K. Seamans, S. B. Floresco, and A. G. Phillips D1 Receptor Modulation of Hippocampal-Prefrontal Cortical Circuits Integrating Spatial Memory with Executive Functions in the Rat J. Neurosci., February 15, 1998; 18(4): 1613 - 1621. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Sawaguchi Attenuation of Preparatory Activity for Reaching Movements by a D1-Dopamine Antagonist in the Monkey Premotor Cortex J Neurophysiol, October 1, 1997; 78(4): 1769 - 1774. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. F. T. Arnsten Catecholamine regulation of the prefrontal cortex J Psychopharmacol, January 1, 1997; 11(2): 151 - 162. [Abstract] [PDF]
|
|
|
|
 |
|
 R. Desimone Neural mechanisms for visual memory and their role in attention PNAS, November 26, 1996; 93(24): 13494 - 13499. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T Aosaki, A. Graybiel, and M Kimura Effect of the nigrostriatal dopamine system on acquired neural responses in the striatum of behaving monkeys Science, July 15, 1994; 265(5170): 412 - 415. [Abstract] [PDF]
|
|
|
|
|
|
T Sawaguchi and P. Goldman-Rakic D1 dopamine receptors in prefrontal cortex: involvement in working memory Science, February 22, 1991; 251(4996): 947 - 950. [Abstract] [PDF]
|
|
|
|
|
|
J. K. Seamans, D. Durstewitz, B. R. Christie, C. F. Stevens, and T. J. Sejnowski Dopamine D1/D5 receptor modulation of excitatory synaptic inputs to layer V prefrontal cortex neurons PNAS, January 2, 2001; 98(1): 301 - 306. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
