| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Neurophysiology, Vol 63, Issue 1 82-104, Copyright © 1990 by APS
ARTICLES |
W. M. Jenkins, M. M. Merzenich, M. T. Ochs, T. Allard and E. Guic-Robles
Coleman Laboratory, University of California, San Francisco 94143-0732.
1. Multiple microelectrode maps of the hand representation within and across the borders of cortical area 3b were obtained before, immediately after, or several weeks after a period of behaviorally controlled hand use. Owl monkeys were conditioned in a task that produced cutaneous stimulation of a limited sector of skin on the distal phalanges of one or more fingers. 2. Analysis of microelectrode mapping experiment data revealed that 1) stimulated skin surfaces were represented over expanded cortical areas. 2) Most of the cutaneous receptive fields recorded within these expanded cortical representational zones were unusually small. 3) The internal topography of representation of the stimulated and immediately surrounding skin surfaces differed greatly from that recorded in control experiments. Representational discontinuities emerged in this map region, and "hypercolumn" distances in this map sector were grossly abnormal. 4) Borders between the representations of individual digits and digit segments commonly shifted. 5) The functionally defined rostral border of area 3b shifted farther rostralward, manifesting either an expansion of the cutaneous area 3b fingertip representation into cortical field 3a or an emergence of a cutaneous input zone in the caudal aspect of this normally predominantly deep-receptor representational field. 6) Significant lateralward translocations of the borders between the representations of the hand and face were recorded in all cases. 7) The absolute locations--and in some cases the areas or magnifications--of representations of many skin surfaces not directly involved in the trained behavior also changed significantly. However, the most striking areal, positional, and topographic changes were related to the representations of the behaviorally stimulated skin in every studied monkey. 3. These experiments demonstrate that functional cortical remodeling of the S1 koniocortical field, area 3b, results from behavioral manipulations in normal adult owl monkeys. We hypothesize that these studies manifest operation of the basic adaptive cortical process(es) underlying cortical contributions to perception and learning.
This article has been cited by other articles:
|
|
 |
|
  R. D. Andreatta Sensorimotor Elements of the Orofacial System: Reviewing the Basics Speech Science and Orofacial Disorders, October 1, 2008; 18(2): 51 - 61. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. V. Gauthier, E. Taub, C. Perkins, M. Ortmann, V. W. Mark, and G. Uswatte Remodeling the Brain: Plastic Structural Brain Changes Produced by Different Motor Therapies After Stroke * Supplemental Material Stroke, May 1, 2008; 39(5): 1520 - 1525. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Marshall, J. J. Ferrera, A. Barnes, Xian Zhang, K. A. O'Brien, M. Chmayssani, J. Hirsch, and R. M. Lazar Brain Activity Associated With Stimulation Therapy of the Visual Borderzone in Hemianopic Stroke Patients Neurorehabil Neural Repair, April 1, 2008; 22(2): 136 - 144. [Abstract] [PDF]
|
|
|
|
 |
|
 J. FitzGerald and J. Fawcett Repair in the central nervous system J Bone Joint Surg Br, November 1, 2007; 89-B(11): 1413 - 1420. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. S. Fischer, S. Aleem, H. Zhou, and T. A. Pham Adult visual experience promotes recovery of primary visual cortex from long-term monocular deprivation Learn. Mem., August 29, 2007; 14(9): 573 - 580. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Smith, P. Lunga, D. Story, N. Harris, J. Le Belle, M. F James, J. D. Pickard, and J. W. Fawcett Inosine promotes recovery of skilled motor function in a model of focal brain injury Brain, April 1, 2007; 130(4): 915 - 925. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Friel, S. Barbay, S. B. Frost, E. J. Plautz, A. M. Stowe, N. Dancause, E. V. Zoubina, and R. J. Nudo Effects of a Rostral Motor Cortex Lesion on Primary Motor Cortex Hand Representation Topography in Primates Neurorehabil Neural Repair, January 1, 2007; 21(1): 51 - 61. [Abstract] [PDF]
|
|
|
|
|
|
R. Galvez, A. P. Weible, and J. F. Disterhoft Cortical barrel lesions impair whisker-CS trace eyeblink conditioning Learn. Mem., January 1, 2007; 14(1-2): 94 - 100. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Rosselet, Y. Zennou-Azogui, and C. Xerri Nursing-induced somatosensory cortex plasticity: temporally decoupled changes in neuronal receptive field properties are accompanied by modifications in activity-dependent protein expression. J. Neurosci., October 18, 2006; 26(42): 10667 - 10676. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. W. Mahncke, B. B. Connor, J. Appelman, O. N. Ahsanuddin, J. L. Hardy, R. A. Wood, N. M. Joyce, T. Boniske, S. M. Atkins, and M. M. Merzenich Memory enhancement in healthy older adults using a brain plasticity-based training program: A randomized, controlled study PNAS, August 15, 2006; 103(33): 12523 - 12528. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Galvez, C. Weiss, A. P. Weible, and J. F. Disterhoft Vibrissa-signaled eyeblink conditioning induces somatosensory cortical plasticity. J. Neurosci., May 31, 2006; 26(22): 6062 - 6068. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kakizawa, T. Miyazaki, D. Yanagihara, M. Iino, M. Watanabe, and M. Kano Maintenance of presynaptic function by AMPA receptor-mediated excitatory postsynaptic activity in adult brain PNAS, December 27, 2005; 102(52): 19180 - 19185. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. G. Rutkowski and N. M. Weinberger Encoding of learned importance of sound by magnitude of representational area in primary auditory cortex PNAS, September 20, 2005; 102(38): 13664 - 13669. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. T. Blake, F. Strata, R. Kempter, and M. M. Merzenich Experience-Dependent Plasticity in S1 Caused by Noncoincident Inputs J Neurophysiol, September 1, 2005; 94(3): 2239 - 2250. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. Chen, R. M. Friedman, and A. W. Roe Optical Imaging of SI Topography in Anesthetized and Awake Squirrel Monkeys J. Neurosci., August 17, 2005; 25(33): 7648 - 7659. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. W. Hickmott Changes in Intrinsic Properties of Pyramidal Neurons in Adult Rat S1 During Cortical Reorganization J Neurophysiol, July 1, 2005; 94(1): 501 - 511. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Raffi and R. M. Siegel Functional Architecture of Spatial Attention in the Parietal Cortex of the Behaving Monkey J. Neurosci., May 25, 2005; 25(21): 5171 - 5186. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Kalisman, G. Silberberg, and H. Markram The neocortical microcircuit as a tabula rasa PNAS, January 18, 2005; 102(3): 880 - 885. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Rosenkranz and J. C Rothwell The effect of sensory input and attention on the sensorimotor organization of the hand area of the human motor cortex J. Physiol., November 15, 2004; 561(1): 307 - 320. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. A. Erchova and M. E. Diamond Rapid Fluctuations in Rat Barrel Cortex Plasticity J. Neurosci., June 30, 2004; 24(26): 5931 - 5941. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Elbert and B. Rockstroh Reorganization of Human Cerebral Cortex: The Range of Changes Following Use and Injury Neuroscientist, April 1, 2004; 10(2): 129 - 141. [Abstract] [PDF]
|
|
|
|
|
|
T. Yang and J. H. R. Maunsell The Effect of Perceptual Learning on Neuronal Responses in Monkey Visual Area V4 J. Neurosci., February 18, 2004; 24(7): 1617 - 1626. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Bao, E. F. Chang, J. D. Davis, K. T. Gobeske, and M. M. Merzenich Progressive Degradation and Subsequent Refinement of Acoustic Representations in the Adult Auditory Cortex J. Neurosci., November 26, 2003; 23(34): 10765 - 10775. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. P. Pluto, R. D. Lane, N. L. Chiaia, A. S. Stojic, and R. W. Rhoades Role of Development in Reorganization of the SI Forelimb-Stump Representation in Fetally, Neonatally, and Adult Amputated Rats J Neurophysiol, September 1, 2003; 90(3): 1842 - 1851. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Nudo Retuning the misfiring brain PNAS, June 24, 2003; 100(13): 7425 - 7427. [Full Text] [PDF]
|
|
|
|
 |
|
 A.F. Apelbaum and M.A. Chaput Rats Habituated to Chronic Feeding Restriction Show a Smaller Increase in Olfactory Bulb Reactivity Compared to Newly Fasted Rats Chem Senses, June 1, 2003; 28(5): 389 - 395. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. LUNDBORG, B. ROSEN, L. KNUTSSON, S. HOLTAS, F. STAHLBERG, and E. M. LARSSON Hand-Arm-Vibration Syndrome (HAVS): Is There a Central Nervous Component? an fMRI Study J Hand Surg Eur Vol., December 1, 2002; 27(6): 514 - 519. [Abstract] [PDF]
|
|
|
|
|
|
T. Elbert, A. Sterr, B. Rockstroh, C. Pantev, M. M. Muller, and E. Taub Expansion of the Tonotopic Area in the Auditory Cortex of the Blind J. Neurosci., November 15, 2002; 22(22): 9941 - 9944. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. W. Hickmott and M. M. Merzenich Local Circuit Properties Underlying Cortical Reorganization J Neurophysiol, September 1, 2002; 88(3): 1288 - 1301. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. T. Blake, F. Strata, A. K. Churchland, and M. M. Merzenich Neural correlates of instrumental learning in primary auditory cortex PNAS, July 23, 2002; 99(15): 10114 - 10119. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F A Lado, A D Legatt, P A LaSala, and S Shinnar Alteration of the cortical motor map in a patient with intractable focal seizures J. Neurol. Neurosurg. Psychiatry, June 1, 2002; 72(6): 812 - 815. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. C. Catania and M. S. Remple Somatosensory cortex dominated by the representation of teeth in the naked mole-rat brain PNAS, April 16, 2002; 99(8): 5692 - 5697. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. M. Ghose, T. Yang, and J. H. R. Maunsell Physiological Correlates of Perceptual Learning in Monkey V1 and V2 J Neurophysiol, April 1, 2002; 87(4): 1867 - 1888. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. R. Siebner, C. Limmer, A. Peinemann, A. Drzezga, B. R. Bloem, M. Schwaiger, and B. Conrad Long-Term Consequences of Switching Handedness: A Positron Emission Tomography Study on Handwriting in "Converted" Left-Handers J. Neurosci., April 1, 2002; 22(7): 2816 - 2825. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H Reddy, D Bendahan, M A Lee, H Johansen-Berg, M Donaghy, D Hilton-Jones, and P M Matthews An expanded cortical representation for hand movement after peripheral motor denervation J. Neurol. Neurosurg. Psychiatry, February 1, 2002; 72(2): 203 - 210. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Braun, U. Heinz, R. Schweizer, K. Wiech, N. Birbaumer, and H. Topka Dynamic organization of the somatosensory cortex induced by motor activity Brain, November 1, 2001; 124(11): 2259 - 2267. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Kilgard, P. K. Pandya, J. Vazquez, A. Gehi, C. E. Schreiner, and M. M. Merzenich Sensory Input Directs Spatial and Temporal Plasticity in Primary Auditory Cortex J Neurophysiol, July 1, 2001; 86(1): 326 - 338. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. ROSEN and G. LUNDBORG The Long Term Recovery Curve in Adults after Median or Ulnar Nerve Repair: A Reference Interval J Hand Surg Eur Vol., June 1, 2001; 26(3): 196 - 200. [Abstract] [PDF]
|
|
|
|
|
|
A. Karl, N. Birbaumer, W. Lutzenberger, L. G. Cohen, and H. Flor Reorganization of Motor and Somatosensory Cortex in Upper Extremity Amputees with Phantom Limb Pain J. Neurosci., May 15, 2001; 21(10): 3609 - 3618. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Nargeot Long-Lasting Reconfiguration of Two Interacting Networks by a Cooperation of Presynaptic and Postsynaptic Plasticity J. Neurosci., May 1, 2001; 21(9): 3282 - 3294. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. Stojic, R. D. Lane, and R. W. Rhoades Intracortical Pathway Involving Dysgranular Cortex Conveys Hindlimb Inputs to S-I Forelimb-Stump Representation of Neonatally Amputated Rats J Neurophysiol, January 1, 2001; 85(1): 407 - 413. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. D. Sanger and M. M. Merzenich Computational Model of the Role of Sensory Disorganization in Focal Task-Specific Dystonia J Neurophysiol, November 1, 2000; 84(5): 2458 - 2464. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Matus Actin-Based Plasticity in Dendritic Spines Science, October 27, 2000; 290(5492): 754 - 758. [Abstract] [Full Text]
|
|
|
|
 |
|
 R. W. V. Boven, R. H. Hamilton, T. Kauffman, J. P. Keenan, and A. Pascual-Leone Tactile spatial resolution in blind Braille readers Neurology, June 27, 2000; 54(12): 2230 - 2236. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. LUNDBORG Brain Plasticity and Hand Surgery: an Overview J Hand Surg Eur Vol., June 1, 2000; 25(3): 242 - 252. [Abstract] [PDF]
|
|
|
|
 |
|
 J. P. Janssen Foundations of a Functional Theory of Human Handedness Theory Psychology, June 1, 2000; 10(3): 375 - 398. [Abstract] [PDF]
|
|
|
|
|
|
P. Tallal The science of literacy: From the laboratory to the classroom PNAS, March 14, 2000; 97(6): 2402 - 2404. [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Lebedev, G. Mirabella, I. Erchova, and M. E. Diamond Experience-dependent Plasticity of Rat Barrel Cortex: Redistribution of Activity across Barrel-columns Cereb Cortex, January 1, 2000; 10(1): 23 - 31. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Braun, R. Schweizer, T. Elbert, N. Birbaumer, and E. Taub Differential Activation in Somatosensory Cortex for Different Discrimination Tasks J. Neurosci., January 1, 2000; 20(1): 446 - 450. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. A. Lenz and N. N. Byl Reorganization in the Cutaneous Core of the Human Thalamic Principal Somatic Sensory Nucleus (Ventral Caudal) in Patients With Dystonia J Neurophysiol, December 1, 1999; 82(6): 3204 - 3212. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Dinkins and S. P. Travers Altered Taste Responses in Adult NST After Neonatal Chorda Tympani Denervation J Neurophysiol, November 1, 1999; 82(5): 2565 - 2578. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Harris, R. S. Petersen, and M. E. Diamond Distribution of tactile learning and its neural basis PNAS, June 22, 1999; 96(13): 7587 - 7591. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Klineberg and G. Murray Osseoperception: Sensory Function and Proprioception Advances in Dental Research, June 1, 1999; 13(1): 120 - 129. [Abstract] [PDF]
|
|
|
|
|
|
C. Xerri, M. M. Merzenich, W. Jenkins, and S. Santucci Representational Plasticity in Cortical Area 3b Paralleling Tactual-motor Skill Acquisition in Adult Monkeys Cereb Cortex, April 1, 1999; 9(3): 264 - 276. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Lane, R. S. Stojic, H. P. Killackey, and R. W. Rhoades Source of Inappropriate Receptive Fields in Cortical Somatotopic Maps From Rats That Sustained Neonatal Forelimb Removal J Neurophysiol, February 1, 1999; 81(2): 625 - 633. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Salimi, T. Brochier, and A. M. Smith Neuronal Activity in Somatosensory Cortex of Monkeys Using a Precision Grip. I. Receptive Fields and Discharge Patterns J Neurophysiol, February 1, 1999; 81(2): 825 - 834. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Huang, M. Armstrong-James, V. Rema, M. E. Diamond, and F. F. Ebner Contribution of Supragranular Layers to Sensory Processing and Plasticity in Adult Rat Barrel Cortex J Neurophysiol, December 1, 1998; 80(6): 3261 - 3271. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. A. Dosher and Z.-L. Lu Perceptual learning reflects external noise filtering and internal noise reduction through channel reweighting PNAS, November 10, 1998; 95(23): 13988 - 13993. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Small and A. Solodkin Review : The Neurobiology of Stroke Rehabilitation Neuroscientist, November 1, 1998; 4(6): 426 - 434. [Abstract] [PDF]
|
|
|
|
|
|
G. LUNDBORG, B. ROSEN, K. LINDSTROM, and S. LINDBERG Artificial Sensibility Based on the Use of Piezoresistive Sensors: Preliminary observations J Hand Surg Eur Vol., October 1, 1998; 23(5): 620 - 626. [Abstract] [PDF]
|
|
|
|
|
|
W. Muhlnickel, T. Elbert, E. Taub, and H. Flor Reorganization of auditory cortex in tinnitus PNAS, August 18, 1998; 95(17): 10340 - 10343. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. B. DAHLIN, Y. KOMOTO-TUFVESSON, and S. SALGEBACK Surgery of the Spastic Hand in Cerebral Palsy: Improvement in stereognosis and hand function after surgery J Hand Surg Eur Vol., June 1, 1998; 23(3): 334 - 339. [Abstract] [PDF]
|
|
|
|
