| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Neurophysiology, Vol 61, Issue 5 900-917, Copyright © 1989 by APS
ARTICLES |
A. M. Aertsen, G. L. Gerstein, M. K. Habib and G. Palm
Max-Planck-Institute for Biological Cybernetics, Tubingen, Federal Republic of Germany.
1. We reexamine the possibilities for analyzing and interpreting the time course of correlation in spike trains simultaneously and separably recorded from two neurons. 2. We develop procedures to quantify and properly normalize the classical joint peristimulus time scatter diagram. These allow separation of the "raw" correlation into components caused by direct stimulus modulations of the single-neuron firing rates and those caused by various types of interaction between the two neurons. 3. A newly developed significance test ("surprise") is applied to evaluate such inferences. 4. Application of the new procedures to simulated spike trains allowed the recovery of the known circuitry. In particular, it proved possible to recover fast stimulus-locked modulations of "effective connectivity," even if they were masked by strong direct stimulus modulations of individual firing rates. These procedures thus present a clearly superior alternative to the commonly used "shift predictor." 5. Adopting a model-based approach, we generalize the classical measures for quantifying a direct interneuronal connection ("efficacy" and "contribution") to include possible stimulus-locked time variations. 6. Application of the new procedures to real spike trains from several different preparations showed that fast stimulus-locked modulations of "effective connectivity" also occur for real neurons.
This article has been cited by other articles:
|
|
 |
|
  L. C. Osborne, S. E. Palmer, S. G. Lisberger, and W. Bialek The Neural Basis for Combinatorial Coding in a Cortical Population Response J. Neurosci., December 10, 2008; 28(50): 13522 - 13531. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Tsujimoto, A. Genovesio, and S. P. Wise Transient Neuronal Correlations Underlying Goal Selection and Maintenance in Prefrontal Cortex Cereb Cortex, December 1, 2008; 18(12): 2748 - 2761. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Temereanca, E. N. Brown, and D. J. Simons Rapid Changes in Thalamic Firing Synchrony during Repetitive Whisker Stimulation J. Neurosci., October 29, 2008; 28(44): 11153 - 11164. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. J. Stam, W. de Haan, A. Daffertshofer, B. F. Jones, I. Manshanden, A. M. van Cappellen van Walsum, T. Montez, J. P. A. Verbunt, J. C. de Munck, B. W. van Dijk, et al. Graph theoretical analysis of magnetoencephalographic functional connectivity in Alzheimer's disease Brain, October 24, 2008; (2008) awn262v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Schrader, S. Grun, M. Diesmann, and G. L. Gerstein Detecting Synfire Chain Activity Using Massively Parallel Spike Train Recording J Neurophysiol, October 1, 2008; 100(4): 2165 - 2176. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. S. Segers, S. C. Nuding, T. E. Dick, R. Shannon, D. M. Baekey, I. C. Solomon, K. F. Morris, and B. G. Lindsey Functional Connectivity in the Pontomedullary Respiratory Network J Neurophysiol, October 1, 2008; 100(4): 1749 - 1769. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Sakamoto, H. Mushiake, N. Saito, K. Aihara, M. Yano, and J. Tanji Discharge Synchrony during the Transition of Behavioral Goal Representations Encoded by Discharge Rates of Prefrontal Neurons Cereb Cortex, September 1, 2008; 18(9): 2036 - 2045. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Diester and A. Nieder Complementary Contributions of Prefrontal Neuron Classes in Abstract Numerical Categorization J. Neurosci., July 30, 2008; 28(31): 7737 - 7747. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Reed, P. Pouget, H.-X. Qi, Z. Zhou, M. R. Bernard, M. J. Burish, J. Haitas, A. B. Bonds, and J. H. Kaas Widespread spatial integration in primary somatosensory cortex PNAS, July 22, 2008; 105(29): 10233 - 10237. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Chakrabarti, M. Zhang, and K. D. Alloway MI Neuronal Responses to Peripheral Whisker Stimulation: Relationship to Neuronal Activity in SI Barrels and Septa J Neurophysiol, July 1, 2008; 100(1): 50 - 63. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Dacks, T. A. Christensen, and J. G. Hildebrand Modulation of Olfactory Information Processing in the Antennal Lobe of Manduca sexta by Serotonin J Neurophysiol, May 1, 2008; 99(5): 2077 - 2085. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Zhou, M. R. Bernard, and A. B. Bonds Deconstruction of Spatial Integrity in Visual Stimulus Detected by Modulation of Synchronized Activity in Cat Visual Cortex J. Neurosci., April 2, 2008; 28(14): 3759 - 3768. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Y. Cohen, P. Pouget, G. F. Woodman, C. R. Subraveti, J. D. Schall, and A. F. Rossi Difficulty of Visual Search Modulates Neuronal Interactions and Response Variability in the Frontal Eye Field J Neurophysiol, November 1, 2007; 98(5): 2580 - 2587. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Shaevitz and F. E. Theunissen Functional Connectivity Between Auditory Areas Field L and CLM and Song System Nucleus HVC in Anesthetized Zebra Finches J Neurophysiol, November 1, 2007; 98(5): 2747 - 2764. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Roy, P. N. Steinmetz, S. S. Hsiao, K. O. Johnson, and E. Niebur Synchrony: A Neural Correlate of Somatosensory Attention J Neurophysiol, September 1, 2007; 98(3): 1645 - 1661. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Paz, E. P. Bauer, and D. Pare Learning-Related Facilitation of Rhinal Interactions by Medial Prefrontal Inputs J. Neurosci., June 13, 2007; 27(24): 6542 - 6551. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. J. Buschman and E. K. Miller Top-Down Versus Bottom-Up Control of Attention in the Prefrontal and Posterior Parietal Cortices Science, March 30, 2007; 315(5820): 1860 - 1862. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. C. Joelving, A. Compte, and C. Constantinidis Temporal Properties of Posterior Parietal Neuron Discharges During Working Memory and Passive Viewing J Neurophysiol, March 1, 2007; 97(3): 2254 - 2266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Sakurai and S. Takahashi Dynamic Synchrony of Firing in the Monkey Prefrontal Cortex during Working-Memory Tasks J. Neurosci., October 4, 2006; 26(40): 10141 - 10153. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Devilbiss, M. E. Page, and B. D. Waterhouse Locus Ceruleus Regulates Sensory Encoding by Neurons and Networks in Waking Animals J. Neurosci., September 27, 2006; 26(39): 9860 - 9872. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Van Hooser, J. A. Heimel, S. Chung, and S. B. Nelson Lack of patchy horizontal connectivity in primary visual cortex of a mammal without orientation maps. J. Neurosci., July 19, 2006; 26(29): 7680 - 7692. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Samonds, Z. Zhou, M. R. Bernard, and A. B. Bonds Synchronous Activity in Cat Visual Cortex Encodes Collinear and Cocircular Contours J Neurophysiol, April 1, 2006; 95(4): 2602 - 2616. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Shapiro and J. Ferbinteanu Relative spike timing in pairs of hippocampal neurons distinguishes the beginning and end of journeys. PNAS, March 14, 2006; 103(11): 4287 - 4292. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Stark, R. Drori, and M. Abeles Partial Cross-Correlation Analysis Resolves Ambiguity in the Encoding of Multiple Movement Features J Neurophysiol, March 1, 2006; 95(3): 1966 - 1975. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. van der Togt, S. Kalitzin, H. Spekreijse, V. A.F. Lamme, and H. Super Synchrony Dynamics in Monkey V1 Predict Success in Visual Detection Cereb Cortex, January 1, 2006; 16(1): 136 - 148. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Ventura, C. Cai, and R. E. Kass Trial-to-Trial Variability and Its Effect on Time-Varying Dependency Between Two Neurons J Neurophysiol, October 1, 2005; 94(4): 2928 - 2939. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Ventura, C. Cai, and R. E. Kass Statistical Assessment of Time-Varying Dependency Between Two Neurons J Neurophysiol, October 1, 2005; 94(4): 2940 - 2947. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Azouz Dynamic Spatiotemporal Synaptic Integration in Cortical Neurons: Neuronal Gain, Revisited J Neurophysiol, October 1, 2005; 94(4): 2785 - 2796. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. J Veredas, F. J Vico, and J.-M. Alonso Factors determining the precision of the correlated firing generated by a monosynaptic connection in the cat visual pathway J. Physiol., September 15, 2005; 567(3): 1057 - 1078. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Hayar, M. T. Shipley, and M. Ennis Olfactory Bulb External Tufted Cells Are Synchronized by Multiple Intraglomerular Mechanisms J. Neurosci., September 7, 2005; 25(36): 8197 - 8208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Salvador, J. Suckling, M. R. Coleman, J. D. Pickard, D. Menon, and E. Bullmore Neurophysiological Architecture of Functional Magnetic Resonance Images of Human Brain Cereb Cortex, September 1, 2005; 15(9): 1332 - 1342. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. E. Kass, V. Ventura, and E. N. Brown Statistical Issues in the Analysis of Neuronal Data J Neurophysiol, July 1, 2005; 94(1): 8 - 25. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kohn and M. A. Smith Stimulus Dependence of Neuronal Correlation in Primary Visual Cortex of the Macaque J. Neurosci., April 6, 2005; 25(14): 3661 - 3673. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Samonds and A. B. Bonds Gamma Oscillation Maintains Stimulus Structure-Dependent Synchronization in Cat Visual Cortex J Neurophysiol, January 1, 2005; 93(1): 223 - 236. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Lei, T. A. Christensen, and J. G. Hildebrand Spatial and Temporal Organization of Ensemble Representations for Different Odor Classes in the Moth Antennal Lobe J. Neurosci., December 8, 2004; 24(49): 11108 - 11119. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K. Lee and M. A. Wilson A Combinatorial Method for Analyzing Sequential Firing Patterns Involving an Arbitrary Number of Neurons Based on Relative Time Order J Neurophysiol, October 1, 2004; 92(4): 2555 - 2573. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Bar-Gad, S. Elias, E. Vaadia, and H. Bergman Complex Locking Rather Than Complete Cessation of Neuronal Activity in the Globus Pallidus of a 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Primate in Response to Pallidal Microstimulation J. Neurosci., August 18, 2004; 24(33): 7410 - 7419. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Hayar, S. Karnup, M. Ennis, and M. T. Shipley External Tufted Cells: A Major Excitatory Element That Coordinates Glomerular Activity J. Neurosci., July 28, 2004; 24(30): 6676 - 6685. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. C. Daly, G. A. Wright, and B. H. Smith Molecular Features of Odorants Systematically Influence Slow Temporal Responses Across Clusters of Coordinated Antennal Lobe Units in the Moth Manduca sexta J Neurophysiol, July 1, 2004; 92(1): 236 - 254. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. A. Erchova and M. E. Diamond Rapid Fluctuations in Rat Barrel Cortex Plasticity J. Neurosci., June 30, 2004; 24(26): 5931 - 5941. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Samonds, J. D. Allison, H. A. Brown, and A. B. Bonds Cooperative synchronized assemblies enhance orientation discrimination PNAS, April 27, 2004; 101(17): 6722 - 6727. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Samonds and A. B. Bonds From Another Angle: Differences in Cortical Coding Between Fine and Coarse Discrimination of Orientation J Neurophysiol, March 1, 2004; 91(3): 1193 - 1202. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Schneidman, W. Bialek, and M. J. Berry II Synergy, Redundancy, and Independence in Population Codes J. Neurosci., December 17, 2003; 23(37): 11539 - 11553. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Compte,, C. Constantinidis, J. Tegner, S. Raghavachari, M. V. Chafee, P. S. Goldman-Rakic, and X.-J. Wang Temporally Irregular Mnemonic Persistent Activity in Prefrontal Neurons of Monkeys During a Delayed Response Task J Neurophysiol, November 1, 2003; 90(5): 3441 - 3454. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Kara and R. C. Reid Efficacy of Retinal Spikes in Driving Cortical Responses J. Neurosci., September 17, 2003; 23(24): 8547 - 8557. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Lee Coherent Oscillations in Neuronal Activity of the Supplementary Motor Area during a Visuomotor Task J. Neurosci., July 30, 2003; 23(17): 6798 - 6809. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. R. Kimpo, F. E. Theunissen, and A. J. Doupe Propagation of Correlated Activity through Multiple Stages of a Neural Circuit J. Neurosci., July 2, 2003; 23(13): 5750 - 5761. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. T. Rolls, L. Franco, N. C. Aggelopoulos, and S. Reece An Information Theoretic Approach to the Contributions of the Firing Rates and the Correlations Between the Firing of Neurons J Neurophysiol, May 1, 2003; 89(5): 2810 - 2822. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Super, C. van der Togt, H. Spekreijse, and V. A. F. Lamme Internal State of Monkey Primary Visual Cortex (V1) Predicts Figure-Ground Perception J. Neurosci., April 15, 2003; 23(8): 3407 - 3414. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Dorn and D. L. Ringach Estimating Membrane Voltage Correlations From Extracellular Spike Trains J Neurophysiol, April 1, 2003; 89(4): 2271 - 2278. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Samonds, J. D. Allison, H. A. Brown, and A. B. Bonds Cooperation between Area 17 Neuron Pairs Enhances Fine Discrimination of Orientation J. Neurosci., March 15, 2003; 23(6): 2416 - 2425. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sirota, J. Csicsvari, D. Buhl, and G. Buzsaki Communication between neocortex and hippocampus during sleep in rodents PNAS, February 18, 2003; 100(4): 2065 - 2069. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Constantinidis and P. S. Goldman-Rakic Correlated Discharges Among Putative Pyramidal Neurons and Interneurons in the Primate Prefrontal Cortex J Neurophysiol, December 1, 2002; 88(6): 3487 - 3497. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. B. Katz, S. A. Simon, and M. A. L. Nicolelis Taste-Specific Neuronal Ensembles in the Gustatory Cortex of Awake Rats J. Neurosci., March 1, 2002; 22(5): 1850 - 1857. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Schwarz and J. P. Welsh Dynamic Modulation of Mossy Fiber System Throughput by Inferior Olive Synchrony: A Multielectrode Study of Cerebellar Cortex Activated by Motor Cortex J Neurophysiol, November 1, 2001; 86(5): 2489 - 2504. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. W. Oram, N. G. Hatsopoulos, B. J. Richmond, and J. P. Donoghue Excess Synchrony in Motor Cortical Neurons Provides Redundant Direction Information With That From Coarse Temporal Measures J Neurophysiol, October 1, 2001; 86(4): 1700 - 1716. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Constantinidis, M. N. Franowicz, and P. S. Goldman-Rakic Coding Specificity in Cortical Microcircuits: A Multiple-Electrode Analysis of Primate Prefrontal Cortex J. Neurosci., May 15, 2001; 21(10): 3646 - 3655. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Roy and K. D. Alloway Coincidence Detection or Temporal Integration? What the Neurons in Somatosensory Cortex Are Doing J. Neurosci., April 1, 2001; 21(7): 2462 - 2473. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Bair, E. Zohary, and W. T. Newsome Correlated Firing in Macaque Visual Area MT: Time Scales and Relationship to Behavior J. Neurosci., March 1, 2001; 21(5): 1676 - 1697. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Roy, S. P. Dear, and K. D. Alloway Long-Range Cortical Synchronization without Concomitant Oscillations in the Somatosensory System of Anesthetized Cats J. Neurosci., March 1, 2001; 21(5): 1795 - 1808. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. N. Baker, R. Spinks, A. Jackson, and R. N. Lemon Synchronization in Monkey Motor Cortex During a Precision Grip Task. I. Task-Dependent Modulation in Single-Unit Synchrony J Neurophysiol, February 1, 2001; 85(2): 869 - 885. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Pauluis, S. N. Baker, and E. Olivier Precise Burst Synchrony in the Superior Colliculus of the Awake Cat during Moving Stimulus Presentation J. Neurosci., January 15, 2001; 21(2): 615 - 627. [Abstract] [Full Text] [PDF]
|
|
