JN Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 40: 1151-1162, 1977;
0022-3077/77 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ransom, B. R.
Right arrow Articles by Nelson, P. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ransom, B. R.
Right arrow Articles by Nelson, P. G.

Journal of Neurophysiology, Vol 40, Issue 5 1151-1162, Copyright © 1977 by APS

ARTICLES

Mouse spinal cord in cell culture. II. Synaptic activity and circuit behavior

B. R. Ransom, C. N. Christian, P. N. Bullock and P. G. Nelson

1. Neurons in cell cultures of fetal mouse spinal cord (SC) and dorsal root ganglia (DRG) develop extensive synaptic interconnections. 2. No spontaneous synaptic activity was detectable in the presence of tetrodotoxin or an elevated magnsium ion concentration, but statistical analysis of evoked excitatory postsynaptic potentials (EPSPs) indicates that the quantal size was 200-250 muV, which was below the noise level of the recording system used. 3. In a sample of eight RDG-SC and seven SC-SC cell pairs linked by EPSPs, the quantal content of the SC-SC EPSPs was about 3.5-fold larger than for the DRG-SC EPSPs. 4. The extrapolated equilibrium potential for the SC-SC EPSP was about 20 mV positive. The IPSP reversed at a membrane potential of 60-80 mV negative. 5. Some examples of the types of synaptic circuits commonly encountered are given. Only one case of electrical coupling between neurons was found.


This article has been cited by other articles:


Home page
 Biophys. JHome page
M.-V. Ehrensperger, C. Hanus, C. Vannier, A. Triller, and M. Dahan
Multiple Association States between Glycine Receptors and Gephyrin Identified by SPT Analysis
Biophys. J., May 15, 2007; 92(10): 3706 - 3718.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. Charrier, M.-V. Ehrensperger, M. Dahan, S. Levi, and A. Triller
Cytoskeleton Regulation of Glycine Receptor Number at Synapses and Diffusion in the Plasma Membrane.
J. Neurosci., August 15, 2006; 26(33): 8502 - 8511.
[Abstract] [Full Text] [PDF]

Home page
 Cold Spring Harb Symp Quant BiolHome page
J.L. Barker, B. Dufy, D.G. Owen, and M. Segal
Excitable Membrane Properties of Cultured Central Nervous System Neurons and Clonal Pituitary Cells
Cold Spring Harb Symp Quant Biol, January 1, 1983; 48(0): 259 - 268.
[Abstract] [PDF]

Home page
 ScienceHome page
R. Macdonald and P. Nelson
Specific-opiate-induced depression of transmitter release from dorsal root ganglion cells in culture
Science, March 31, 1978; 199(4336): 1449 - 1451.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online