JN Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Neurophysiol 39: 909-923, 1976;
0022-3077/76 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Parnas, I.
Right arrow Articles by Parnas, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Parnas, I.
Right arrow Articles by Parnas, H.

Journal of Neurophysiology, Vol 39, Issue 4 909-923, Copyright © 1976 by APS

ARTICLES

Theoretical analysis of parameters leading to frequency modulation along an inhomogeneous axon

I. Parnas, S. Hochstein and H. Parnas

1. Theoretical computations were conducted on a computer model of a segmented, nonhomogeneous axon to understand the mechanism of frequency block of conduction. 2. The model is based on the Hodgkin-Huxley equations modified in several ways to better describe the cockroach axon. We used cockroach parameters where available. 3. The increase in fiber radius was spread over a series of segments to approximate a taper. We found that a taper allows a larger overall increase in fiber diameter than a single step to be successfully passed. 4. We studied effects on a train of impulses. The modified equations included effects due to changes in extracellular potassium concentration resulting from the repetitive firing of the axon. 5. An increase in diameter which allows a single spike to pass blocks the subsequent impulses in a train at the taper if potassium concentration variability is introduced. This could explain the low-pass filter characteristics of axon constrictions. 6. Results of the model fit well with the experiemental spike shape and height. Data were computed for the refractory period and its dependence on the taper parameters.


This article has been cited by other articles:


Home page
 J. Neurosci.Home page
W. A. Hossain, S. D. Antic, Y. Yang, M. N. Rasband, and D. K. Morest
Where Is the Spike Generator of the Cochlear Nerve? Voltage-Gated Sodium Channels in the Mouse Cochlea
J. Neurosci., July 20, 2005; 25(29): 6857 - 6868.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
L. Lopez-Aguado, J. M. Ibarz, P. Varona, and O. Herreras
Structural Inhomogeneities Differentially Modulate Action Currents and Population Spikes Initiated in the Axon or Dendrites
J Neurophysiol, November 1, 2002; 88(5): 2809 - 2820.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
L. Zhou and S. Y. Chiu
Computer Model for Action Potential Propagation Through Branch Point in Myelinated Nerves
J Neurophysiol, January 1, 2001; 85(1): 197 - 210.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
D. W. Hochman and P. A. Schwartzkroin
Chloride-Cotransport Blockade Desynchronizes Neuronal Discharge in the "Epileptic" Hippocampal Slice
J Neurophysiol, January 1, 2000; 83(1): 406 - 417.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
I. L. Kopysova and D. Debanne
Critical Role of Axonal A-Type K+ Channels and Axonal Geometry in the Gating of Action Potential Propagation along CA3 Pyramidal Cell Axons: A Simulation Study
J. Neurosci., September 15, 1998; 18(18): 7436 - 7451.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online